Relation Results

Summary

Name QARS1
Full Name Glutamine--tRNA ligase
Synonyms Glutaminyl-tRNA synthetase, GlnRS |
Primary ID P47897
Links - -
Type protein
Relations 1
Function Glutamine--tRNA ligase (PubMed:26869582). Plays a critical role in brain development (PubMed:24656866).

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Type: Score: Layout: SPV 
0.2QARS1Multiaminoacyl-tRNA synthetase

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Relations
Regulator
Mechanism
target
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+ QARS1form complex img/form-complex.png binding Multiaminoacyl-tRNA synthetase 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270358 Homo sapiens
pmid sentence
In mammalian cells, eight cytoplasmic aminoacyl-tRNA synthetases (AARS), and three non-synthetase proteins, reside in a large multi-tRNA synthetase complex (MSC). the MSC is suggested to be a super-complex of two identical, symmetrically arranged sub-units, each containing a single copy of the constituents, with the exception of LysRS which is present as a dimer in each sub-unit (Figure ​(Figure1B,1B, adapted from (27,28)). The sub-units are proposed to be joined by dimers of AspRS and the ProRS domain of GluProRS, and possibly by LysRS tetramers (20). Four AARSs containing GST-like domains important in protein-protein interactions form a MetRS-AIMP3–GluProRS–AIMP2 core of the complex (27,29). These proteins, together with AspRS, and possibly LeuRS and IleRS (30), form a distinct sub-complex denoted as sub-complex I (27). Sub-complex II consists of AIMP1, GlnRS, ArgRS, a dimer of LysRS, and AIMP2 (which is shared by both sub-complexes).
Publications: 1 Organism: Homo Sapiens
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