Summary

Name SLC1A6
Full Name Excitatory amino acid transporter 4
Synonyms Sodium-dependent glutamate/aspartate transporter, Solute carrier family 1 member 6 | EAAT4
Primary ID P48664
Links - -
Type protein
Relations 3
Function Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7791878). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable).

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Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png binding SLC1A6 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SLC1A6 0.255
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity img/direct-activation.png relocalization glutamic acid 0.8
Publications: 1 Organism: Homo Sapiens