| + |
Multiaminoacyl-tRNA synthetase | down-regulates quantity 
chemical modification
|
glutamic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270381 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28271488 |
Aminoacyl-tRNA synthetases (AARSs) are essential enzymes that specifically aminoacylate one tRNA molecule by the cognate amino acid. In mammals, nine synthetases, those specific for amino acids Arg, Asp, Gln, Glu, Ile, Leu, Lys, Met and Pro, associate into a multi-aminoacyl-tRNA synthetase complex, an association which is believed to play a key role in the cellular organization of translation, but also in the regulation of the translational and nontranslational functions of these enzymes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glutamic acid | up-regulates activity 
chemical activation
|
GRM4 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264074 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25042998 |
Metabotropic glutamate receptors are class C G-protein-coupled receptors which respond to the neurotransmitter glutamate |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glutamic acid | up-regulates activity
chemical activation
|
GRIK5 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264474 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27586965 |
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and exerts its biological activity through a variety of receptors. Glutamate receptors (GluRs) are divided into two major classes on the basis of the mechanism by which they relay their signal: the ionotropic glutamate receptors (iGluRs), which are ligand-gated cation channels, and the metabotropic glutamate receptors (mGluRs) that are G protein-coupled receptors |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glutamic acid | up-regulates quantity
precursor of
|
Glu-tRNA(Glu) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270386 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28271488 |
Aminoacyl-tRNA synthetases (AARSs) are essential enzymes that specifically aminoacylate one tRNA molecule by the cognate amino acid. In mammals, nine synthetases, those specific for amino acids Arg, Asp, Gln, Glu, Ile, Leu, Lys, Met and Pro, associate into a multi-aminoacyl-tRNA synthetase complex, an association which is believed to play a key role in the cellular organization of translation, but also in the regulation of the translational and nontranslational functions of these enzymes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC1A3 | up-regulates quantity
relocalization
|
glutamic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264802 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26687113 |
After release from presynaptic nerve terminals, glutamate is quickly removed from the synaptic cleft by a family of five glutamate transporters, the so-called excitatory amino acid transporters (EAAT1-5). In glia or in neurons, EAATs mediate the re-uptake of synaptically released glutamate via the coupled co-transport of three Na+, one H+, and one glutamate, in counter-transport to one K+. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GLUD1 | down-regulates quantity
chemical modification
|
glutamic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266917 |
|
|
Bos taurus |
|
| pmid |
sentence |
| 11254391 |
Glutamate dehydrogenase is found in all organisms and catalyses the oxidative deamination of l-glutamate to 2-oxoglutarate. |
|
| Publications: |
1 |
Organism: |
Bos Taurus |
| + |
glutamic acid | up-regulates activity
chemical activation
|
KAR |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264694 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15919192 |
Glutamate receptor ion channels mediate excitatory responses at the majority of CNS synapses. The glutamate receptor ion channels (iGluRs) are abundantly expressed in the brain and spinal cord and mediate responses at the vast majority of excitatory synapses. Mammalian iGluRs are encoded by 18 genes that assemble to form four major families, the AMPA, kainate, NMDA and delta receptors. There are four AMPA receptor genes (GluR1–4); five kainate receptor genes (GluR5–7, plus KA1 and KA2); seven NMDA receptor genes (NR1, NR2A-D, NR3A and NR3B); and two delta subunits. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glutamatergic synapse |
| + |
glutamic acid | up-regulates activity
chemical activation
|
GRIA2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264609 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30825796 |
In the mammalian brain the majority of fast excitatory neurotransmission is carried out by α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-sensitive ionotropic glutamate receptors located within the post-synaptic density of glutamatergic synapses |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glutamic acid | up-regulates activity
chemical activation
|
AMPA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264696 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15919192 |
Glutamate receptor ion channels mediate excitatory responses at the majority of CNS synapses. The glutamate receptor ion channels (iGluRs) are abundantly expressed in the brain and spinal cord and mediate responses at the vast majority of excitatory synapses. Mammalian iGluRs are encoded by 18 genes that assemble to form four major families, the AMPA, kainate, NMDA and delta receptors. There are four AMPA receptor genes (GluR1–4); five kainate receptor genes (GluR5–7, plus KA1 and KA2); seven NMDA receptor genes (NR1, NR2A-D, NR3A and NR3B); and two delta subunits. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Dopaminergic Synapse, Glutamatergic synapse |
| + |
glutamic acid | up-regulates activity
chemical activation
|
GRIK1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264470 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27586965 |
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and exerts its biological activity through a variety of receptors. Glutamate receptors (GluRs) are divided into two major classes on the basis of the mechanism by which they relay their signal: the ionotropic glutamate receptors (iGluRs), which are ligand-gated cation channels, and the metabotropic glutamate receptors (mGluRs) that are G protein-coupled receptors |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glutamic acid | up-regulates activity
chemical activation
|
NMDA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264692 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24564659 |
Excitatory synaptic transmission in the mammalian brain is mediated primarily by the amino acid glutamate, activating two different groups of glutamate receptors: ionotropic and metabotropic. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Dopaminergic Synapse, Glutamatergic synapse |
| + |
glutamic acid | up-regulates activity
chemical activation
|
GRM3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264075 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25042998 |
Metabotropic glutamate receptors are class C G-protein-coupled receptors which respond to the neurotransmitter glutamate |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GOT2 | down-regulates quantity
chemical modification
|
glutamic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266923 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31422819 |
Both isoforms [GOT! AND GOT2] catalyze the reversible interconversion of oxaloacetate and glutamate into aspartate and α-ketoglutarate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glutamic acid | up-regulates activity
chemical activation
|
GRM5 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264070 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25042998 |
Metabotropic glutamate receptors are class C G-protein-coupled receptors which respond to the neurotransmitter glutamate |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glutamic acid | up-regulates activity
chemical activation
|
GRIK3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264472 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27586965 |
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and exerts its biological activity through a variety of receptors. Glutamate receptors (GluRs) are divided into two major classes on the basis of the mechanism by which they relay their signal: the ionotropic glutamate receptors (iGluRs), which are ligand-gated cation channels, and the metabotropic glutamate receptors (mGluRs) that are G protein-coupled receptors |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glutamic acid | up-regulates activity
chemical activation
|
NMDA receptor_2B |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264129 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12871085 |
The NMDA receptor, a ligand-gated ion channel composed of the NR1 and NR2 subunits, is located mainly at synapses of CNS neurons. Each receptor has two binding sites for glycine and two binding sites for glutamate |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC1A1 | up-regulates quantity
relocalization
|
glutamic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264804 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26687113 |
After release from presynaptic nerve terminals, glutamate is quickly removed from the synaptic cleft by a family of five glutamate transporters, the so-called excitatory amino acid transporters (EAAT1-5). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC1A2 | up-regulates quantity
relocalization
|
glutamic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264803 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26687113 |
After release from presynaptic nerve terminals, glutamate is quickly removed from the synaptic cleft by a family of five glutamate transporters, the so-called excitatory amino acid transporters (EAAT1-5). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glutamic acid | up-regulates activity
chemical activation
|
GRM7 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264072 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25042998 |
Metabotropic glutamate receptors are class C G-protein-coupled receptors which respond to the neurotransmitter glutamate |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glutamic acid | up-regulates activity
chemical activation
|
GRID1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264468 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27586965 |
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and exerts its biological activity through a variety of receptors. Glutamate receptors (GluRs) are divided into two major classes on the basis of the mechanism by which they relay their signal: the ionotropic glutamate receptors (iGluRs), which are ligand-gated cation channels, and the metabotropic glutamate receptors (mGluRs) that are G protein-coupled receptors |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glutamic acid | up-regulates activity
chemical activation
|
GRIA1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264616 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30825796 |
In the mammalian brain the majority of fast excitatory neurotransmission is carried out by α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-sensitive ionotropic glutamate receptors located within the post-synaptic density of glutamatergic synapses |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261432 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15115814 |
AMPA glutamate receptor subunit (GluR1) |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| + |
glutamic acid | up-regulates activity
chemical activation
|
GRID2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264469 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27586965 |
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and exerts its biological activity through a variety of receptors. Glutamate receptors (GluRs) are divided into two major classes on the basis of the mechanism by which they relay their signal: the ionotropic glutamate receptors (iGluRs), which are ligand-gated cation channels, and the metabotropic glutamate receptors (mGluRs) that are G protein-coupled receptors |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glutamic acid | up-regulates activity
chemical activation
|
NMDA receptor_2A |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264128 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12871085 |
The NMDA receptor, a ligand-gated ion channel composed of the NR1 and NR2 subunits, is located mainly at synapses of CNS neurons. Each receptor has two binding sites for glycine and two binding sites for glutamate |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glutamic acid | up-regulates activity
chemical activation
|
GRM2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264071 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25042998 |
Metabotropic glutamate receptors are class C G-protein-coupled receptors which respond to the neurotransmitter glutamate |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GLUD2 | down-regulates quantity
chemical modification
|
glutamic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268558 |
|
|
Bos taurus |
|
| pmid |
sentence |
| 11254391 |
Glutamate dehydrogenase is found in all organisms and catalyses the oxidative deamination of l-glutamate to 2-oxoglutarate. |
|
| Publications: |
1 |
Organism: |
Bos Taurus |
| + |
glutamic acid | up-regulates activity
chemical activation
|
GRIA3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264610 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30825796 |
In the mammalian brain the majority of fast excitatory neurotransmission is carried out by α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-sensitive ionotropic glutamate receptors located within the post-synaptic density of glutamatergic synapses |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glutamic acid | up-regulates activity
chemical activation
|
GRM6 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264076 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25042998 |
Glutamate is the major excitatory neurotransmitter in the central nervous system. Metabotropic glutamate receptors are class C G-protein-coupled receptors which respond to the neurotransmitter glutamate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GPT2 | down-regulates quantity
chemical modification
|
glutamic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266926 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11863375 |
Alanine aminotransferase (ALT) catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate, and thereby has a key role in the intermediary metabolism of glucose and amino acids. Two ALT isoenzymes are known to exist, but only one ALT gene has been cloned, GPT. In this study, we cloned a homolog of GPT and named it GPT2, and the corresponding protein ALT2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glutamic acid | up-regulates activity
chemical activation
|
MGluR |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264688 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25042998 |
Metabotropic glutamate receptors are class C G-protein-coupled receptors which respond to the neurotransmitter glutamate |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glutamatergic synapse |
| + |
glutamic acid | up-regulates activity
chemical activation
|
GRIA4 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264611 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30825796 |
In the mammalian brain the majority of fast excitatory neurotransmission is carried out by α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-sensitive ionotropic glutamate receptors located within the post-synaptic density of glutamatergic synapses |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC25A12 | down-regulates quantity
relocalization
|
glutamic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265154 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12084073 |
Aralar1 and citrin are members of the subfamily of calcium-binding mitochondrial carriers and correspond to two isoforms of the mitochondrial aspartate/glutamate carrier (AGC). These proteins are activated by Ca2+ acting on the external side of the inner mitochondrial membrane. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glutamic acid | up-regulates activity
chemical activation
|
GRM1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264069 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25042998 |
Metabotropic glutamate receptors are class C G-protein-coupled receptors which respond to the neurotransmitter glutamate |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glutamic acid | up-regulates activity
chemical activation
|
NMDA receptor_2D |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264131 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12871085 |
The NMDA receptor, a ligand-gated ion channel composed of the NR1 and NR2 subunits, is located mainly at synapses of CNS neurons. Each receptor has two binding sites for glycine and two binding sites for glutamate |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glutamic acid | up-regulates activity
chemical activation
|
NMDA receptor_2C |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264130 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12871085 |
The NMDA receptor, a ligand-gated ion channel composed of the NR1 and NR2 subunits, is located mainly at synapses of CNS neurons. Each receptor has two binding sites for glycine and two binding sites for glutamate |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glutamic acid | up-regulates quantity
|
AminoAcids |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264752 |
|
|
|
|
| pmid |
sentence |
| 29259120 |
All extant life employs the same 20 amino acids for protein biosynthesis |
|
| Publications: |
1 |
| + |
SLC1A7 | up-regulates quantity
relocalization
|
glutamic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264806 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26687113 |
After release from presynaptic nerve terminals, glutamate is quickly removed from the synaptic cleft by a family of five glutamate transporters, the so-called excitatory amino acid transporters (EAAT1-5). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glutamic acid | up-regulates activity
chemical activation
|
GRIK4 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264473 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27586965 |
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and exerts its biological activity through a variety of receptors. Glutamate receptors (GluRs) are divided into two major classes on the basis of the mechanism by which they relay their signal: the ionotropic glutamate receptors (iGluRs), which are ligand-gated cation channels, and the metabotropic glutamate receptors (mGluRs) that are G protein-coupled receptors |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC1A6 | up-regulates quantity
relocalization
|
glutamic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264805 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26687113 |
After release from presynaptic nerve terminals, glutamate is quickly removed from the synaptic cleft by a family of five glutamate transporters, the so-called excitatory amino acid transporters (EAAT1-5). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glutamic acid | up-regulates activity
chemical activation
|
GRM8 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264073 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25042998 |
Metabotropic glutamate receptors are class C G-protein-coupled receptors which respond to the neurotransmitter glutamate |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC25A13 | down-regulates quantity
relocalization
|
glutamic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265155 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12084073 |
Aralar1 and citrin are members of the subfamily of calcium-binding mitochondrial carriers and correspond to two isoforms of the mitochondrial aspartate/glutamate carrier (AGC). These proteins are activated by Ca2+ acting on the external side of the inner mitochondrial membrane. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glutamic acid | up-regulates activity
chemical activation
|
GRIK2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264471 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27586965 |
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and exerts its biological activity through a variety of receptors. Glutamate receptors (GluRs) are divided into two major classes on the basis of the mechanism by which they relay their signal: the ionotropic glutamate receptors (iGluRs), which are ligand-gated cation channels, and the metabotropic glutamate receptors (mGluRs) that are G protein-coupled receptors |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
L-glutamine zwitterion | up-regulates quantity
precursor of
|
glutamic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267308 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33179964 |
The first two reactions catalyzed by TGART are sequential and produce FGAR, which is then acted upon by the third enzyme in the pathway, formylglycinamidine synthase (PFAS/FGAMS).The transferred ammonia is then used to convert FGAR to FGAM. The FGAMS protein exhibits interesting biophys ical properties and will be covered later in this review. The FGAM produced by FGAMS is then converted into AIR by the AIRS domain of TGART, resulting in a five membered ring closure. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PFAS | up-regulates quantity
chemical modification
|
glutamic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267312 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33179964 |
The first two reactions catalyzed by TGART are sequential and produce FGAR, which is then acted upon by the third enzyme in the pathway, formylglycinamidine synthase (PFAS/FGAMS).The transferred ammonia is then used to convert FGAR to FGAM. The FGAMS protein exhibits interesting biophys ical properties and will be covered later in this review. The FGAM produced by FGAMS is then converted into AIR by the AIRS domain of TGART, resulting in a five membered ring closure. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
glutamic acid