3.0
Summary
| Name |  NUMBView Modifications |
| Full Name | Protein numb homolog |
| Synonyms | h-Numb, Protein S171 |
| Primary ID | P49757 |
| Links |  -  -  |
| Type | protein |
| Relations | 20 |
| Pathways | NOTCH Signaling and Myogenesis, Satellite: NOTCH |
| Function | Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CAMK1 | down-regulates 
phosphorylation
|
NUMB | 0.34 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AAK1 | up-regulates 
phosphorylation
|
NUMB | 0.472 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AAK1 |
phosphorylation
|
NUMB | 0.472 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MSI1 | down-regulates
binding
|
NUMB | 0.457 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SATB1 | down-regulates quantity by repression 
transcriptional regulation
|
NUMB | 0.343 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LNX2 | down-regulates quantity by destabilization
polyubiquitination
|
NUMB | 0.625 |
| Publications: | 1 | Organism: | In Vitro | |
| + | NUMB | down-regulates
binding
|
MDM2 | 0.456 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MSI2 | down-regulates quantity by repression
transcriptional regulation
|
NUMB | 0.43 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NUMB | down-regulates
|
NOTCH | 0.79 |
| Publications: | 2 | |||
| Tissue: | Skeletal Muscle | |||
| + | NUMB | up-regulates 
|
TP53 | 0.531 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKCI | down-regulates
phosphorylation
|
NUMB | 0.761 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SLC30A9 | down-regulates quantity by destabilization
ubiquitination
|
NUMB | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NUMB | up-regulates
binding
|
ITCH | 0.598 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NUMB | down-regulates quantity by destabilization
ubiquitination
|
NOTCH1 | 0.79 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | NOTCH Signaling and Myogenesis | |||
| + | LNX1 | down-regulates
ubiquitination
|
NUMB | 0.73 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MDM2 | down-regulates
ubiquitination
|
NUMB | 0.456 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NUMB | down-regulates
binding
|
GLI1 | 0.606 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SIAH1 | down-regulates
ubiquitination
|
NUMB | 0.409 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NUMB | up-regulates
binding
|
TP53 | 0.531 |
| Publications: | 1 | Organism: | Homo Sapiens | |