Summary

Name DIO1
Full Name Type I iodothyronine deiodinase
Synonyms 5DI, DIOI, Type 1 DI, Type-I 5'-deiodinase | ITDI1, TXDI1
Primary ID P49895
Links - -
Type protein
Relations 7
Pathways Thyroid Hormone Metabolism
Inhibitors 6-propyl-2-thiouracil
Function Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.

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Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png chemical inhibition DIO1 0.8
Publications: 1 Organism: Homo Sapiens
Tissue: Thyroid Gland
Pathways:Thyroid Hormone Metabolism
+ down-regulates quantity img/direct_inhibition.png chemical modification L-thyroxine 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation DIO1 0.2
Publications: 1 Organism: Rattus Norvegicus
Pathways:Thyroid Hormone Metabolism
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation DIO1 0.2
Publications: 1 Organism: Rattus Norvegicus
Pathways:Thyroid Hormone Metabolism
+ up-regulates quantity img/direct-activation.png chemical modification 3,3',5'-triiodothyronine 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ up-regulates quantity img/direct-activation.png chemical modification iodide 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation DIO1 0.2
Publications: 1 Organism: Rattus Norvegicus
Pathways:Thyroid Hormone Metabolism