| + |
DIO1 | up-regulates quantity 
chemical modification
|
iodide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266954 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34674502 |
Three different deiodinases have been described: iodothyronine deiodinase 1 (DIO1), DIO2, and DIO3. Deiodination is the first step in the activation/inactivation process of THs and involves the removal of removes one iodine atom from the outer tyrosyl ring of T4 to produce T3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
DIO1 | down-regulates quantity 
chemical modification
|
L-thyroxine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266944 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1400883 |
The type I 5' iodothyronine deiodinase (5' DI) catalyzes the deiodination of T4 to the biologically active hormone T3 and accounts for a significant fraction of its production. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
DIO1 | up-regulates quantity
chemical modification
|
3,3',5'-triiodothyronine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266945 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1400883 |
The type I 5' iodothyronine deiodinase (5' DI) catalyzes the deiodination of T4 to the biologically active hormone T3 and accounts for a significant fraction of its production. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
IFNG | down-regulates quantity by repression 
transcriptional regulation
|
DIO1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267487 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 9397972 |
From the results in Figs. 1-3, it is clear that several cytokines reduce the expression of 5’-DI mRNA and enzymatic activity in FRTL-5 cells. These include TNF-a, IL-lb and INF-y. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | Thyroid Hormone Metabolism |
| + |
6-propyl-2-thiouracil | down-regulates activity
chemical inhibition
|
DIO1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267280 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27347897 |
The activity of D1 but not D2 or D3 is inhibited by 6n-propylthiouracil (PTU). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Thyroid Gland |
| Pathways: | Thyroid Hormone Metabolism |
| + |
IL1B | down-regulates quantity by repression
transcriptional regulation
|
DIO1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267486 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 9397972 |
From the results in Figs. 1-3, it is clear that several cytokines reduce the expression of 5’-DI mRNA and enzymatic activity in FRTL-5 cells. These include TNF-a, IL-lb and INF-y. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | Thyroid Hormone Metabolism |
| + |
TNF | down-regulates quantity by repression
transcriptional regulation
|
DIO1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267485 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 9397972 |
From the results in Figs. 1-3, it is clear that several cytokines reduce the expression of 5’-DI mRNA and enzymatic activity in FRTL-5 cells. These include TNF-a, IL-lb and INF-y. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | Thyroid Hormone Metabolism |
3.0
DIO1
- 
- 