| + |
3-iodo-L-tyrosine | up-regulates quantity 
precursor of
|
3,3',5'-triiodothyronine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268128 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28153798 |
The synthesis of T3 and T4 is achieved through the transfer of an iodophenoxyl group from a MIT or DIT residue called a “donor” onto a DIT residue called an “acceptor”. TPO seems to be primarily responsible for catalyzing the oxidations of iodotyrosines. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
3,3',5'-triiodothyronine | up-regulates activity
binding
|
THR |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267276 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29407449 |
T3 binds its receptor (TR) in the nucleus. TRs are ligand-dependent transcription factors belonging to the type II group of NHRs. TRs are encoded by two genes, Thra and Thrb. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
3,3',5'-triiodothyronine | up-regulates activity
binding, chemical activation
|
THRB |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267254 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29407449 |
T3 binds its receptor (TR) in the nucleus. TRs are ligand-dependent transcription factors belonging to the type II group of NHRs. TRs are encoded by two genes, Thra and Thrb. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258384 |
|
|
Rattus norvegicus |
Liver |
| pmid |
sentence |
| 2158622 |
We determined the affinity for T3 and analog binding characteristics of the translational products of c-erbA a- and /3-probes together with hepatic nuclear extracts. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Rattus Norvegicus |
| Tissue: |
Hypophysis |
| Pathways: | Thyroid Hormone Metabolism |
| + |
L-thyroxine | up-regulates quantity
precursor of
|
3,3',5'-triiodothyronine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266940 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12746313 |
Human type III iodothyronine deiodinase (D3) catalyzes the conversion of T(4) to rT(3) and of T(3) to 3, 3'-diiodothyronine (T2) by inner-ring deiodination. Like types I and II iodothyronine deiodinases, D3 protein contains selenocysteine (SeC) in the highly conserved core catalytic center at amino acid position 144. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268127 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8755651 |
Type II iodothyronine deiodinase (DII), which catalyzes deiodination of thyroxine (T4) exclusively on the outer ring (5’-position) to yield T3 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267042 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34674502 |
Thyroid hormone (TH) deiodinases play a pivotal role in the functional diversification of TH signaling. They are involved in development, growth, and metabolic processes, and act in a cell-specific manner in the fine regulation of TH homeostasis. TH deiodinases catalyze activation and inactivation of THs through the removal of one iodine atom in the outer or inner ring of the TH molecule.  |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266943 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1400883 |
The type I 5' iodothyronine deiodinase (5' DI) catalyzes the deiodination of T4 to the biologically active hormone T3 and accounts for a significant fraction of its production. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266948 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8755651 |
Type II iodothyronine deiodinase (DII), which catalyzes deiodination of thyroxine (T4) exclusively on the outer ring (5’-position) to yield T3 |
|
| Publications: |
5 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
SLC16A2 | down-regulates quantity 
relocalization
|
3,3',5'-triiodothyronine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267139 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28153798 |
T4 and T3 are released from the thyroid cell through transporters present at the basolateral plasma membrane of thyrocytes (Fig. 1). The most important transporter known to be responsible for thyroid hormone transport is the SLC16A2 monocarboxylate transporter 8 (MCT8), which can promote both uptake and efflux of TH and is involved in the release of TH from the thyroid gland. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
TPO | up-regulates quantity
chemical modification
|
3,3',5'-triiodothyronine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267039 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28153798 |
The synthesis of T3 and T4 is achieved through the transfer of an iodophenoxyl group from a MIT or DIT residue called a “donor” onto a DIT residue called an “acceptor”. TPO seems to be primarily responsible for catalyzing the oxidations of iodotyrosines. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
3,3',5'-triiodothyronine | up-regulates 
|
Skeletal_muscle_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267619 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24692351 |
Skeletal muscle has been recognized as a key TH target for contractile function, regeneration, and transport as well as for metabolism and glucose disposal (237, 238). TH stimulation favors transition to fast-twitch fibers and transition to a faster myosin heavy chain (MHC) form. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
DIO1 | up-regulates quantity
chemical modification
|
3,3',5'-triiodothyronine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266945 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1400883 |
The type I 5' iodothyronine deiodinase (5' DI) catalyzes the deiodination of T4 to the biologically active hormone T3 and accounts for a significant fraction of its production. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
3,3',5'-triiodothyronine | up-regulates
|
Fatty_Acid_Biosynthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267488 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24692351 |
TH stimulates both lipolysis and lipogenesis, although the direct action is lipolysis with lipogenesis thought to be stimulated to restore fat stores. Fatty acids produced from TH-induced lipolysis are the substrate for the increase in thermogenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Liver |
| Pathways: | Thyroid Hormone Metabolism |
| + |
3,3',5'-triiodothyronine | up-regulates activity
chemical activation, binding
|
THRA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258385 |
|
|
Rattus norvegicus |
Liver |
| pmid |
sentence |
| 2158622 |
We determined the affinity for T3 and analog binding characteristics of the translational products of c-erbA a- and /3-probes together with hepatic nuclear extracts. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267255 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29407449 |
T3 binds its receptor (TR) in the nucleus. TRs are ligand-dependent transcription factors belonging to the type II group of NHRs. TRs are encoded by two genes, Thra and Thrb. |
|
| Publications: |
2 |
Organism: |
Rattus Norvegicus, Homo Sapiens |
| Tissue: |
Hypophysis |
| Pathways: | Thyroid Hormone Metabolism |
| + |
DIO | up-regulates quantity
chemical modification
|
3,3',5'-triiodothyronine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267044 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34674502 |
Thyroid hormone (TH) deiodinases play a pivotal role in the functional diversification of TH signaling. They are involved in development, growth, and metabolic processes, and act in a cell-specific manner in the fine regulation of TH homeostasis. TH deiodinases catalyze activation and inactivation of THs through the removal of one iodine atom in the outer or inner ring of the TH molecule.  |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267809 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20978344 |
The deiodinase family of enzymes controls the tissue-specific activation and inactivation of the prohormone thyroxine (T4) |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
3,3',5'-triiodothyronine | up-regulates
|
Gluconeogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267490 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24692351 |
It has been previously established that T3 stimulates gluconeogenesis, especially in the hyperthyroid state, and that hypothyroidism is associated with reduced gluconeogenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Liver |
| + |
3,3',5'-triiodothyronine | up-regulates activity
chemical activation
|
DIO |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270246 |
|
|
Homo sapiens |
COS Cell |
| pmid |
sentence |
| 12746313 |
Human type III iodothyronine deiodinase (D3) catalyzes the conversion of T(4) to rT(3) and of T(3) to 3, 3'-diiodothyronine (T2) by inner-ring deiodination. Like types I and II iodothyronine deiodinases, D3 protein contains selenocysteine (SeC) in the highly conserved core catalytic center at amino acid position 144. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
3,5-diiodo-L-tyrosine | up-regulates quantity
precursor of
|
3,3',5'-triiodothyronine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268121 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28153798 |
The synthesis of T3 and T4 is achieved through the transfer of an iodophenoxyl group from a MIT or DIT residue called a “donor” onto a DIT residue called an “acceptor”. TPO seems to be primarily responsible for catalyzing the oxidations of iodotyrosines. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
3,3',5'-triiodothyronine | up-regulates
|
Thermogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267491 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24692351 |
TH plays a significant role in energy expenditure through both central and peripheral actions. TH maintains basal metabolic rate, facilitates adaptive thermogenesis, modulates appetite and food intake, and regulates body weight. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
DIO3 | up-regulates quantity
chemical modification
|
3,3',5'-triiodothyronine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266942 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12746313 |
Human type III iodothyronine deiodinase (D3) catalyzes the conversion of T(4) to rT(3) and of T(3) to 3, 3'-diiodothyronine (T2) by inner-ring deiodination. Like types I and II iodothyronine deiodinases, D3 protein contains selenocysteine (SeC) in the highly conserved core catalytic center at amino acid position 144. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
3.0
3,3',5'-triiodothyronine