Relation Results

Summary

Name CHN2
Full Name Beta-chimaerin
Synonyms Beta-chimerin, Rho GTPase-activating protein 3 | ARHGAP3, BCH
Primary ID P52757
Links - -
Type protein
Relations 5
Function GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play ...
View More

Viewer

Type: Score: Layout: SPV 
0.2710.20.20.20.63PRKCDCHN2LCKFYNSRCRAC1

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PRKCDdown-regulates img/direct_inhibition.png phosphorylation CHN2 0.271
Identifier Residue Sequence Organism Cell Line
SIGNOR-164687 Ser171 EKVSRRLsRSKNEPR Homo sapiens
pmid sentence
A novel cross-talk in diacylglycerol signaling: the rac-gap beta2-chimaerin is negatively regulated by protein kinase cdelta-mediated phosphorylation. phosphorylation of beta2-chimaerin on ser(169) located in the sh2-c1 domain linker region via protein kinase cdelta, which retained beta2-chimaerin in the cytosol and prevented its c1 domain-mediated translocation to membranes
Publications: 1 Organism: Homo Sapiens
+ LCKdown-regulates activity img/direct_inhibition.png phosphorylation CHN2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276240 Tyr153 KMTTNPIyEHIGYAT Homo sapiens JURKAT Cell
pmid sentence
We now demonstrate Lck-dependent phosphorylation of beta2-chimaerin in response to TCR triggering. We identify Tyr-153 as the Lck-dependent phosphorylation residue and show that its phosphorylation negatively regulates membrane stabilization of beta2-chimaerin, decreasing its GAP activity to Rac. 
Publications: 1 Organism: Homo Sapiens
+ FYNdown-regulates img/direct_inhibition.png phosphorylation CHN2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-155709 Tyr21 VSSDAEEyQPPIWKS Homo sapiens
pmid sentence
Ere we report that beta2-chimaerin is tyrosine-phosphorylated by src-family kinases (sfks) upon cell stimulation with epidermal growth factor (egf). these results suggest tyr-21 phosphorylation as a novel, sfk-dependent mechanism that negatively regulates beta2-chimaerin rac-gap activity.
Publications: 1 Organism: Homo Sapiens
+ SRCdown-regulates img/direct_inhibition.png phosphorylation CHN2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-155713 Tyr21 VSSDAEEyQPPIWKS Homo sapiens
pmid sentence
Here we report that beta2-chimaerin is tyrosine-phosphorylated by src-family kinases (sfks) upon cell stimulation with epidermal growth factor (egf). Mutational analysis identified tyr-21 in the n-terminal regulatory region as a major phosphorylation site. these results suggest tyr-21 phosphorylation as a novel, sfk-dependent mechanism that negatively regulates beta2-chimaerin rac-gap activity.
Publications: 1 Organism: Homo Sapiens
+ CHN2down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.63
Identifier Residue Sequence Organism Cell Line
SIGNOR-260500 Homo sapiens HEK-293 Cell
pmid sentence
We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity among regulators, but also that the inactivating RhoGAPs are less selective than the activating RhoGEFs (p-value=0.02)(Supplementary Table 2).
Publications: 1 Organism: Homo Sapiens
a simple tooltip