Summary

Name IST1
Full Name IST1 homolog
Synonyms hIST1, Charged multivesicular body protein 8, CHMP8, Putative MAPK-activating protein PM28 | KIAA0174
Primary ID P53990
Links - -
Type protein
Relations 1
Function ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation (PubMed:19129479, PubMed:26040712, PubMed:28242692). Is required for efficient abscission during cytokinesis (PubMed:19129479). Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129480, PubMed:19129479). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (PubMed:28242692). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888).

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Relations

Regulator Mechanism target score ℹ
+ IST1up-regulates activity img/direct-activation.png relocalization SPAST 0.535
Publications: 1 Organism: Homo Sapiens