| + |
SPAST | up-regulates 
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269045 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 15716377 |
Using purified components, we also show that Spastin interacts directly with microtubules and is sufficient for severing. These studies suggest that defects in microtubule severing are a cause of axonal degeneration in human disease. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
SPAST | up-regulates
cleavage
|
Microtubule_polimerization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269046 |
|
|
in vitro |
|
| pmid |
sentence |
| 15716377 |
Using real-time imaging, we show that Spastin severs microtubules when added to permeabilized, cytosol-depleted cells stably expressing GFP-tubulin. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
NRF1 | up-regulates quantity by expression
transcriptional regulation
|
SPAST |
0.344 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254885 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22574173 |
we demonstrate that SPAST transcription is positively regulated by NRF1 and SOX11. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX11 | up-regulates quantity by expression
transcriptional regulation
|
SPAST |
0.371 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254886 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22574173 |
we demonstrate that SPAST transcription is positively regulated by NRF1 and SOX11. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IST1 | up-regulates activity 
relocalization
|
SPAST |
0.535 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269047 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 23897888 |
Our results suggest that inclusion of IST1 into the ESCRT complex allows recruitment of spastin to promote fission of recycling tubules from the endosome. Thus, we reveal a novel cellular role for MT severing and identify a mechanism by which endosomal recycling can be coordinated with the degradative machinery. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SPAST
- 
- 