| + |
SIRT5 | up-regulates activity 
post translational modification
|
HMGCS2 |
0.353 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267642 |
Lys310 |
PFCKMVQkSLARLMF |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24315375 |
We demonstrate that SIRT5 regu-lates succinylation of the rate-limiting ketogenicenzyme 3-hydroxy-3-methylglutaryl-CoA synthase 2(HMGCS2) both in vivo and in vitro.|Succinylation of Lysine Residues within the SubstrateBinding Pocket Inhibits HMGCS2 Activity|Here, we use a label-freequantitative proteomic approach to characterizethe lysine succinylome in liver mitochondria and itsregulation by the desuccinylase SIRT5 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267641 |
Lys83 |
YNNVEAGkYTVGLGQ |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24315375 |
We demonstrate that SIRT5 regu-lates succinylation of the rate-limiting ketogenicenzyme 3-hydroxy-3-methylglutaryl-CoA synthase 2(HMGCS2) both in vivo and in vitro.|Succinylation of Lysine Residues within the SubstrateBinding Pocket Inhibits HMGCS2 Activity|Here, we use a label-freequantitative proteomic approach to characterizethe lysine succinylome in liver mitochondria and itsregulation by the desuccinylase SIRT5 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
HMGCS2 | down-regulates quantity 
chemical modification
|
acetoacetyl-CoA(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282483 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11479731 |
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (mHMGS: EC 4.1.3.5) catalyses the first step of ketogenesis from acetyl-CoA and acetoacetyl-CoA and is considered to be the main control step in ketogenesis (Hegardt 1999). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HMGCS2 | up-regulates quantity
chemical modification
|
coenzyme A(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282484 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11479731 |
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (mHMGS: EC 4.1.3.5) catalyses the first step of ketogenesis from acetyl-CoA and acetoacetyl-CoA and is considered to be the main control step in ketogenesis (Hegardt 1999). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HMGCS2 | up-regulates quantity
chemical modification
|
(3S)-3-hydroxy-3-methylglutaryl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282485 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11479731 |
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (mHMGS: EC 4.1.3.5) catalyses the first step of ketogenesis from acetyl-CoA and acetoacetyl-CoA and is considered to be the main control step in ketogenesis (Hegardt 1999). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HMGCS2 | down-regulates quantity
chemical modification
|
acetoacetyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267659 |
|
|
|
|
| pmid |
sentence |
| 29597274 |
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase (mHS, EC 2.3.3.10) catalyzes the condensation reaction between acetyl-CoA and acetoacetyl-CoA in ketone body synthesis |
|
| Publications: |
1 |
| + |
HMGCS2 | up-regulates quantity
chemical modification
|
(3S)-3-hydroxy-3-methylglutaryl-CoA(5-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267660 |
|
|
|
|
| pmid |
sentence |
| 29597274 |
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase (mHS, EC 2.3.3.10) catalyzes the condensation reaction between acetyl-CoA and acetoacetyl-CoA in ketone body synthesis |
|
| Publications: |
1 |
| + |
HMGCS2 | down-regulates quantity
chemical modification
|
acetyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267658 |
|
|
|
|
| pmid |
sentence |
| 29597274 |
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase (mHS, EC 2.3.3.10) catalyzes the condensation reaction between acetyl-CoA and acetoacetyl-CoA in ketone body synthesis |
|
| Publications: |
1 |
| + |
HMGCS2 | down-regulates quantity
chemical modification
|
acetyl-CoA(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282482 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11479731 |
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (mHMGS: EC 4.1.3.5) catalyses the first step of ketogenesis from acetyl-CoA and acetoacetyl-CoA and is considered to be the main control step in ketogenesis (Hegardt 1999). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
HMGCS2
- 
- 