3.0
Summary
| Name |  STX17View Modifications |
| Full Name | Syntaxin-17 |
| Synonyms | STX17_HUMAN | |
| Primary ID | P56962 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion (PubMed:23217709, PubMed:25686604, PubMed:28306502). STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604, PubMed:28306502). May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | TBK1 | up-regulates activity 
phosphorylation
|
STX17 | 0.298 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ABL1 | down-regulates activity 
phosphorylation
|
STX17 | 0.2 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | RUBCNL | up-regulates activity
binding
|
STX17 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | STX17 | form complex 
binding
|
STX17-VAMP8 SNARE complex | 0.92 |
| Publications: | 1 | Organism: | Homo Sapiens | |