| + |
STX17 | form complex 
binding
|
STX17-VAMP8 SNARE complex |
0.924 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273709 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23217709 |
Here, we identify syntaxin 17 (Stx17) as the autophagosomal SNARE required for fusion with the endosome/lysosome. Stx17 localizes to the outer membrane of completed autophagosomes but not to the isolation membrane (unclosed intermediate structures); for this reason, the lysosome does not fuse with the isolation membrane. Stx17 interacts with SNAP-29 and the endosomal/lysosomal SNARE VAMP8. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VAMP8 | form complex
binding
|
STX17-VAMP8 SNARE complex |
0.921 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273711 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23217709 |
Here, we identify syntaxin 17 (Stx17) as the autophagosomal SNARE required for fusion with the endosome/lysosome. Stx17 localizes to the outer membrane of completed autophagosomes but not to the isolation membrane (unclosed intermediate structures); for this reason, the lysosome does not fuse with the isolation membrane. Stx17 interacts with SNAP-29 and the endosomal/lysosomal SNARE VAMP8. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COG tethering complex | up-regulates activity 
binding
|
STX17-VAMP8 SNARE complex |
0.391 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280769 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23378023 |
Multisubunit tethering complexes (MTCs) positively regulate vesicular fusion by as yet unclear mechanism. In this study we provide evidence that the MTC COG enhances the assembly of fusogenic Golgi SNARE complexes and concomitantly prevents nonfusogenic tSNARE interactions. This capability is possibly mediated by multiple direct interactions of COG subunits and specific Golgi SNAREs and SM (Sec1/Munc18) proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STX17-VAMP8 SNARE complex | up-regulates activity 
|
Membrane_fusion |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273712 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23217709 |
Here, we identify syntaxin 17 (Stx17) as the autophagosomal SNARE required for fusion with the endosome/lysosome. Stx17 localizes to the outer membrane of completed autophagosomes but not to the isolation membrane (unclosed intermediate structures); for this reason, the lysosome does not fuse with the isolation membrane. Stx17 interacts with SNAP-29 and the endosomal/lysosomal SNARE VAMP8. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SNAP29 | form complex
binding
|
STX17-VAMP8 SNARE complex |
0.943 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273710 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23217709 |
Here, we identify syntaxin 17 (Stx17) as the autophagosomal SNARE required for fusion with the endosome/lysosome. Stx17 localizes to the outer membrane of completed autophagosomes but not to the isolation membrane (unclosed intermediate structures); for this reason, the lysosome does not fuse with the isolation membrane. Stx17 interacts with SNAP-29 and the endosomal/lysosomal SNARE VAMP8. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
STX17-VAMP8 SNARE complex