+ |
Caspase 1 complex | up-regulates activity
cleavage
|
GSDMD |
0.634 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-256415 |
Asp275 |
CLHNFLTdGVPAEGA |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
26375003 |
Co-expression of GSDMD with caspase-1, 4, 5 or 11 but not apoptotic caspases (caspase-2, 8 and 9) in 293T cells induced the same cleavage of GSDMD|inflammatory caspases specifically cleave GSDMD after the 272FLTD275 (or 273LLSD276) sequence | |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Inflammosome Activation |
+ |
CASP4 | up-regulates activity
cleavage
|
GSDMD |
0.636 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-256417 |
Asp275 |
CLHNFLTdGVPAEGA |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
26375003 |
Co-expression of GSDMD with caspase-1, 4, 5 or 11 but not apoptotic caspases (caspase-2, 8 and 9) in 293T cells induced the same cleavage of GSDMD|inflammatory caspases specifically cleave GSDMD after the 272FLTD275 (or 273LLSD276) sequence | |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CASP5 | up-regulates activity
cleavage
|
GSDMD |
0.609 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-256418 |
Asp275 |
CLHNFLTdGVPAEGA |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
26375003 |
Co-expression of GSDMD with caspase-1, 4, 5 or 11 but not apoptotic caspases (caspase-2, 8 and 9) in 293T cells induced the same cleavage of GSDMD|inflammatory caspases specifically cleave GSDMD after the 272FLTD275 (or 273LLSD276) sequence | |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
GSDMD | up-regulates
|
Pyroptosis |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-256416 |
|
|
|
|
pmid |
sentence |
26375003 |
These results establish that proteolytic cleavage at Asp275 in GSDMDis sufficient to instructmammalian cells to undergo pyroptosis |
|
Publications: |
1 |
Pathways: | Inflammosome Activation |