+ |
CDK1 |
phosphorylation
|
RAB5B |
0.331 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-69233 |
Ser123 |
KELQRQAsPSIVIAL |
Homo sapiens |
|
pmid |
sentence |
10403367 |
Cdc2 kinase preferentially phosphorylates ser-123 of rab5b. More work will be required to establish how phosphorylation of the three rab5 isoforms influences their function in the endocytic pathway |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
LRRK2 | up-regulates activity
phosphorylation
|
RAB5B |
0.618 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-276873 |
Thr6 |
tARPNGQP |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
25605758 |
Using recombinant proteins, we show here that LRRK2 phosphorylates Rab5b at its Thr6 residue in in vitro kinase assays with mass spectrophotometry analysis. Phosphorylation of Rab5b by LRRK2 on the threonine residue was confirmed by western analysis using cells stably expressing LRRK2 G2019S. The phosphomimetic T6D mutant exhibited stronger GTPase activity than that of the wild-type Rab5b. In addition, phosphorylation of Rab5b by LRRK2 also exhibited GTPase activity stronger than that of the unphosphorylated Rab5b protein. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
RAB5B | form complex
binding
|
Early Endosome |
0.46 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-276874 |
|
|
Homo sapiens |
|
pmid |
sentence |
19924646 |
The Rab proteins primarily localized to the EE include Rab5 and Rab4, which regulate distinct early endocytic events. In addition to these two Rab proteins, some of the other less well-characterized Rabs at the EE include Rab10 , Rab14 , Rab21 and Rab22 |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
LYST | down-regulates activity
binding
|
RAB5B |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266002 |
|
|
Drosophila melanogaster |
|
pmid |
sentence |
33725482 |
Mauve interacts with Rab5, Msps, and gamma-tubulin|Mauve/LYST opposes Rab5, which promotes vesicle fusion affecting PCM recruitment |
|
Publications: |
1 |
Organism: |
Drosophila Melanogaster |