Relation Results

Summary

Name RAB5B
Full Name Ras-related protein Rab-5B
Synonyms RAB5B_HUMAN
Primary ID P61020
Links - -
Type protein
Relations 4
Function Protein transport. Probably involved in vesicular traffic (By similarity).

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Type: Score: Layout: SPV 
0.3290.6110.4690.2CDK1RAB5BLRRK2Early EndosomeLYST

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ CDK1 img/unknown.png phosphorylation RAB5B 0.329
Identifier Residue Sequence Organism Cell Line
SIGNOR-69233 Ser123 KELQRQAsPSIVIAL Homo sapiens
pmid sentence
Cdc2 kinase preferentially phosphorylates ser-123 of rab5b. More work will be required to establish how phosphorylation of the three rab5 isoforms influences their function in the endocytic pathway
Publications: 1 Organism: Homo Sapiens
+ LRRK2up-regulates activity img/direct-activation.png phosphorylation RAB5B 0.611
Identifier Residue Sequence Organism Cell Line
SIGNOR-276873 Thr6 tARPNGQP Homo sapiens HeLa Cell
pmid sentence
 Using recombinant proteins, we show here that LRRK2 phosphorylates Rab5b at its Thr6 residue in in vitro kinase assays with mass spectrophotometry analysis. Phosphorylation of Rab5b by LRRK2 on the threonine residue was confirmed by western analysis using cells stably expressing LRRK2 G2019S. The phosphomimetic T6D mutant exhibited stronger GTPase activity than that of the wild-type Rab5b. In addition, phosphorylation of Rab5b by LRRK2 also exhibited GTPase activity stronger than that of the unphosphorylated Rab5b protein.
Publications: 1 Organism: Homo Sapiens
+ RAB5Bform complex img/form-complex.png binding Early Endosome 0.469
Identifier Residue Sequence Organism Cell Line
SIGNOR-276874 Homo sapiens
pmid sentence
The Rab proteins primarily localized to the EE include Rab5 and Rab4, which regulate distinct early endocytic events. In addition to these two Rab proteins, some of the other less well-characterized Rabs at the EE include Rab10 , Rab14 , Rab21 and Rab22
Publications: 1 Organism: Homo Sapiens
+ LYSTdown-regulates activity img/direct_inhibition.png binding RAB5B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-266002 Drosophila melanogaster
pmid sentence
Mauve interacts with Rab5, Msps, and gamma-tubulin|Mauve/LYST opposes Rab5, which promotes vesicle fusion affecting PCM recruitment
Publications: 1 Organism: Drosophila Melanogaster
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