Summary

Name B2M
Full Name Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]
Synonyms B2MG_HUMAN |
Primary ID P61769
Links - -
Type protein
Relations 5
Function Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).

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Relations

Regulator Mechanism target score ℹ
+ NfKb-p65/p50up-regulates quantity by expression img/indirect-activation.png transcriptional regulation B2M 0.349
Publications: 1 Organism: Homo Sapiens
+ USF1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation B2M 0.2
Publications: 1 Organism: Homo Sapiens
+ USF2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation B2M 0.2
Publications: 1 Organism: Homo Sapiens
+ B2Mform complex img/form-complex.png binding Class I MHC 0.2
Publications: 1 Organism: In Vitro
+ RELAup-regulates quantity by expression img/indirect-activation.png transcriptional regulation B2M 0.265
Publications: 1 Organism: Homo Sapiens