| Name
|
 ETF1
|
| Full Name |
Eukaryotic peptide chain release factor subunit 1 |
| Synonyms |
Eukaryotic release factor 1, eRF1, Protein Cl1, TB3-1 | ERF1, RF1, SUP45L1 |
| Primary ID |
P62495 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
1 |
| Function |
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (PubMed:7990965, PubMed:24486019). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371). |
3.0
binding