Summary

Name ID2
Full Name DNA-binding protein inhibitor ID-2
Synonyms Class B basic helix-loop-helix protein 26, bHLHb26, Inhibitor of DNA binding 2, Inhibitor of differentiation 2 | BHLHB26
Primary ID Q02363
Links - -
Type protein
Relations 14
Function Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation ID2 0.372
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ID2 0.447
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ID2 0.447
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ID2 0.25
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png binding MYOD/HEB 0.566
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding TCF3 0.608
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ID2 0.295
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding MYOD1 0.561
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding TCF4 0.618
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding MYOD/E12E47 0.584
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ID2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination ID2 0.347
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding MYOD/E2-2 0.59
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding TCF12 0.571
Publications: 1 Organism: Mus Musculus