Summary

Name TCF3
Full Name Transcription factor E2-alpha
Synonyms Class B basic helix-loop-helix protein 21, bHLHb21, Immunoglobulin enhancer-binding factor E12/E47, Immunoglobulin transcription factor 1, Kappa-E2-binding factor, Transcription factor 3, TCF-3, Transcription factor ITF-1 | BHLHB21, E2A, ITF1
Primary ID P15923
Links - -
Type protein
Relations 30
Pathways P38 Signaling and Myogenesis
Function Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Together with TCF15, required for the mesenchymal to epithelial transition. Dimers bind DNA on E-box motifs

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation TCF3 0.407
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates activity img/direct-activation.png phosphorylation TCF3 0.455
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:P38 Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png phosphorylation TCF3 0.2
Publications: 5 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TCF3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation TCF3 0.381
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation TCF3 0.368
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding TCF3 0.608
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CDH1 0.318
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding MYOD/E12E47 0.797
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ down-regulates activity img/direct_inhibition.png binding TCF3 0.55
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1A 0.323
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding TCF3 0.478
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BBC3 0.277
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TCF3 0.318
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation TCF3 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding TCF3 0.444
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TCF3 0.493
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CR2 0.287
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MYOD1 0.797
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:P38 Signaling and Myogenesis
+ up-regulates img/direct-activation.png phosphorylation TCF3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding TCF3 0.656
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding TCF3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding TCF3 0.278
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png TCF3 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NOTCH1 0.444
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation TCF3 0.2
Publications: 1 Organism: Mus Musculus