Summary

Name ID3
Full Name DNA-binding protein inhibitor ID-3
Synonyms Class B basic helix-loop-helix protein 25, bHLHb25, Helix-loop-helix protein HEIR-1, ID-like protein inhibitor HLH 1R21, Inhibitor of DNA binding 3, Inhibitor of differentiation 3 | 1R21, BHLHB25, HEIR1
Primary ID Q02535
Links - -
Type protein
Relations 12
Function Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation ID3 0.349
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ID3 0.2
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png binding TCF12 0.482
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding MYOD/E12E47 0.499
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation ID3 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding TCF3 0.55
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation ID3 0.254
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation ID3 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding MYOD/E2-2 0.46
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding MYOD/HEB 0.465
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding TCF4 0.473
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ID3 0.2
Publications: 1 Organism: Homo Sapiens