3.0
Summary
| Name |  ID3View Modifications |
| Full Name | DNA-binding protein inhibitor ID-3 |
| Synonyms | Class B basic helix-loop-helix protein 25, bHLHb25, Helix-loop-helix protein HEIR-1, ID-like protein inhibitor HLH 1R21, Inhibitor of DNA binding 3, Inhibitor of differentiation 3 | 1R21, BHLHB25, HEIR1 |
| Primary ID | Q02535 |
| Links |  -  -  |
| Type | protein |
| Relations | 12 |
| Function | Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CDK2 | down-regulates 
phosphorylation
|
ID3 | 0.348 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NFIA | down-regulates quantity
transcriptional regulation
|
ID3 | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | GDF5 | up-regulates quantity by expression 
transcriptional regulation
|
ID3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ID3 | down-regulates activity
binding
|
MYOD/HEB | 0.462 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | ID3 | down-regulates activity
binding
|
TCF4 | 0.47 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | GDNF | up-regulates quantity by expression
transcriptional regulation
|
ID3 | 0.2 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| + | ID3 | down-regulates activity
binding
|
TCF3 | 0.546 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | ID3 | down-regulates activity
binding
|
MYOD/E12E47 | 0.496 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | ID3 | down-regulates activity
binding
|
TCF12 | 0.479 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | NFIX | down-regulates quantity
transcriptional regulation
|
ID3 | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | ID3 | down-regulates activity
binding
|
MYOD/E2-2 | 0.458 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | NFIB | down-regulates quantity
transcriptional regulation
|
ID3 | 0.253 |
| Publications: | 1 | Organism: | Mus Musculus | |