Summary

Name ITK
Full Name Tyrosine-protein kinase ITK/TSK
Synonyms Interleukin-2-inducible T-cell kinase, IL-2-inducible T-cell kinase, Kinase EMT, T-cell-specific kinase, Tyrosine-protein kinase Lyk | EMT, LYK
Primary ID Q08881
Links - -
Type protein
Relations 18
Function Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation ITK
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ITK 0.86
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CD28 0.58
Publications: 5 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CD28 0.58
Publications: 3
+ up-regulates img/direct-activation.png phosphorylation TEC 1.00
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BMX 0.96
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation BTK 0.86
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation ITK 0.58
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation SIGLEC10 0.43
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLCG1 0.52
Publications: 1 Organism: Homo Sapiens