Summary

Name BTK
Full Name Tyrosine-protein kinase BTK
Synonyms Agammaglobulinemia tyrosine kinase, ATK, B-cell progenitor kinase, BPK, Bruton tyrosine kinase | AGMX1, ATK, BPK
Primary ID Q06187
Links - -
Type protein
Relations 34
Pathways B-cell activation
Inhibitors ibrutinib; 9-(1-Methyl-4-pyrazolyl)-1-[1-(1-oxoprop-2-enyl)-2,3-dihydroindol-6-yl]-2-benzo[h][1,6]naphthyridinone
Function Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation BTK 0.391
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PLCG2 0.77
Publications: 4 Organism: Homo Sapiens
Pathways:B-cell activation
+ up-regulates activity img/direct-activation.png phosphorylation DAPP1 0.656
Publications: 2 Organism: In Vitro,
+ up-regulates img/direct-activation.png phosphorylation ITK 0.469
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TEC 0.467
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BMX 0.34
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BTK 0.467
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BTK 0.343
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BTK 0.469
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png dephosphorylation BTK 0.265
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation BTK 0.343
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GTF2I 0.537
Publications: 3 Organism: Chlorocebus Aethiops
+ img/unknown.png phosphorylation WAS 0.731
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation WAS 0.731
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DDX41 0.421
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation BTK 0.567
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
+ up-regulates img/direct-activation.png phosphorylation BTK 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
+ up-regulates activity img/direct-activation.png phosphorylation BTK 0.503
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BTK 0.519
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
+ up-regulates activity img/direct-activation.png phosphorylation STAT5A 0.482
Publications: 1 Organism: In Vitro
Pathways:B-cell activation
+ up-regulates img/direct-activation.png phosphorylation PLCG2 0.77
Publications: 2 Organism: Homo Sapiens
Pathways:B-cell activation
+ down-regulates img/direct_inhibition.png chemical inhibition BTK 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BTK 0.49
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation BTK 0.459
Publications: 1 Organism: Mus Musculus
Pathways:B-cell activation
+ down-regulates activity img/direct_inhibition.png chemical inhibition BTK 0.8
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation GTF2I 0.537
Publications: 1 Organism: Homo Sapiens