Summary

Name KCNH2
Full Name Potassium voltage-gated channel subfamily H member 2
Synonyms Eag homolog, Ether-a-go-go-related gene potassium channel 1, ERG-1, Eag-related protein 1, Ether-a-go-go-related protein 1, H-ERG, hERG-1, hERG1, Voltage-gated potassium channel subunit Kv11.1 | ERG, ERG1, HERG
Primary ID Q12809
Links - -
Type protein
Relations 11
Inhibitors 3-(dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)-9-phenanthrenyl]-1-propanol; cisapride; Terfenadine
Function Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (PubMed:18559421, PubMed:26363003, PubMed:27916661).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation KCNH2 0.31
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition KCNH2 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition KCNH2 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination KCNH2 0.272
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation KCNH2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding KCNH2 0.29
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition KCNH2 0.8
Publications: 2 Organism: Homo Sapiens, In Vitro