3.0
Summary
| Name |  MAP4K2View Modifications |
| Full Name | Mitogen-activated protein kinase kinase kinase kinase 2 |
| Synonyms | B lymphocyte serine/threonine-protein kinase, Germinal center kinase, GC kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, MEKKK 2, Rab8-interacting protein | GCK, RAB8IP |
| Primary ID | Q12851 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Pathways | SAPK/JNK Signaling |
| Function | Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAP4K2 | up-regulates activity 
phosphorylation
|
MAP4K2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | SAPK/JNK Signaling | |||
| + | MAP4K2 | up-regulates activity
phosphorylation
|
PSMD2 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | MAPK8IP1 | down-regulates 
binding
|
MAP4K2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | SAPK/JNK Signaling | |||
| + | MAP4K2 | up-regulates
binding
|
MAP3K1 | 0.546 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | SAPK/JNK Signaling | |||
| + | TRAF2 | up-regulates
binding
|
MAP4K2 | 0.514 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | SAPK/JNK Signaling | |||