Summary

Name MAPK8IP1
Full Name C-Jun-amino-terminal kinase-interacting protein 1
Synonyms JIP-1, JNK-interacting protein 1, Islet-brain 1, IB-1, JNK MAP kinase scaffold protein 1, Mitogen-activated protein kinase 8-interacting protein 1 | IB1, JIP1, PRKM8IP
Primary ID Q9UQF2
Links - -
Type protein
Relations 22
Pathways SAPK/JNK Signaling
Function The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells.

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation MAPK8IP1 0.88
Publications: 5 Organism: Chlorocebus Aethiops
Pathways:SAPK/JNK Signaling
+ up-regulates activity img/direct-activation.png phosphorylation MAPK8IP1 0.765
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK8IP1 0.88
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:SAPK/JNK Signaling
+ down-regulates img/direct_inhibition.png binding MAPK8 0.88
Publications: 4 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ down-regulates img/direct_inhibition.png binding RBPJ 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAPK8IP1 0.454
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAPK8IP1 0.638
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAPK8IP1 0.29
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ down-regulates img/direct_inhibition.png binding MAPK9 0.765
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAP3K10 0.523
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAP2K7 0.715
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAPK8IP1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MAP3K12 0.534
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MAP4K2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ down-regulates img/direct_inhibition.png binding NOTCH1 0.271
Publications: 1 Organism: Homo Sapiens