| + |
NFX1 | down-regulates quantity by repression 
transcriptional regulation
|
HLA-DRA |
0.412 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266224 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7964459 |
A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Ub:E2 | up-regulates activity 
ubiquitination
|
NFX1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271015 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PABPC1 | up-regulates activity
binding
|
NFX1 |
0.351 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261052 |
|
|
Homo sapiens |
Culture Condition:3-hydroxybenzoate-grown Cell |
| pmid |
sentence |
| 17267499 |
We identifiednew protein partners of NFX1-123, including several cytoplasmic poly(A) binding proteins (PABPCs) thatinteracted with NFX1-123 through its N-terminal PAM2 motif. Central to our findings were our observations that PABPCs copurify with NFX1-123, that a PAM2 motif is present in NFX1, and this motif and the PABPCs are important in the enhancement of hTERT activity by NFX1-123. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PABPC4 | up-regulates activity
binding
|
NFX1 |
0.249 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261051 |
|
|
Homo sapiens |
Culture Condition:3-chlorobenzoate-grown Cell |
| pmid |
sentence |
| 17267499 |
We identifiednew protein partners of NFX1-123, including several cytoplasmic poly(A) binding proteins (PABPCs) thatinteracted with NFX1-123 through its N-terminal PAM2 motif. Central to our findings were our observations that PABPCs copurify with NFX1-123, that a PAM2 motif is present in NFX1, and this motif and the PABPCs are important in the enhancement of hTERT activity by NFX1-123. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFX1 | up-regulates quantity by expression 
transcriptional regulation
|
TERT |
0.503 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-226015 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17267499 |
NFX1-123 augments the activation of hTERT expression through interactions with PABPCs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFX1 | up-regulates activity
binding
|
PABPC1 |
0.351 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-226011 |
|
|
Homo sapiens |
HFK Cell |
| pmid |
sentence |
| 17267499 |
NFX1-123 augments the activation of hTERT expression through interactions with PABPCs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFX1 | up-regulates quantity by expression
transcriptional regulation
|
TERT |
0.503 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261050 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17267499 |
NFX1-123 positively regulated hTERT expression, as its knockdown decreased hTERT mRNA levels and telomerase activity and its overexpression increased telomerase activity. NFX1-123 was found to interact with cytoplasmic poly(A) binding proteins (PABPCs), and together they synergistically augmented expression from the hTERT promoter when activated by HPV16 E6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFX1 | up-regulates activity
binding
|
SIN3A |
0.381 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-226360 |
|
|
Homo sapiens |
HFK Cell |
| pmid |
sentence |
| 18505829 |
we investigated the mechanism of NFX1-91 repression of the hTERT promoter and demonstrated that NFX1-91 interacts with the corepressor mSin3A/HDAC to maintain the deacetylated status at the hTERT promoter, thus providing a mechanism by which NFX1-91 represses hTERT expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NFX1
- 
- 