| + |
MAP4K1 | down-regulates activity 
phosphorylation
|
LCP2 |
0.769 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274153 |
Ser376 |
PRKQLSESSDDDYDD |
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 17353368 |
The serine/threonine kinase HPK-1 phosphorylates serine 376 of SLP-76 and induces the interaction with 14-3-3 proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP4K1 | up-regulates 
phosphorylation
|
LCP2 |
0.769 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-153613 |
Ser376 |
SSFPQSAsLPPYFSQ |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 17353368 |
The serine/threonine kinase hpk-1 phosphorylates serine 376 of slp-76 and induces the interaction with 14-3-3 proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZAP70 | up-regulates
phosphorylation
|
LCP2 |
0.798 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-42956 |
Tyr113 |
SSFEEDDyESPNDDQ |
Homo sapiens |
|
| pmid |
sentence |
| 8702662 |
A fourth peptide derived from slp-76 encompassing tyr residues 423 and 426 was also phosphorylated by zap-70 but with a 10-15-fold lesser efficiency compared to tyr-113, _128, and _145. Phosphorylation of slp-76 by the zap-70 protein-tyrosine kinase is required for t-cell receptor function |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-46855 |
Tyr113 |
SSFEEDDyESPNDDQ |
Homo sapiens |
|
| pmid |
sentence |
| 9047237 |
Zap-70 phosphorylates slp-76 at specific sites that allow vav sh2 domain bindingwe also show by in vitro and in vivo analysis that two slp-76 pyesp motifs (y113 and y128) mediate binding, the first being more efficient. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-42960 |
Tyr128 |
DGEDDGDyESPNEEE |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 8702662 |
A fourth peptide derived from slp-76 encompassing tyr residues 423 and 426 was also phosphorylated by zap-70 but with a 10-15-fold lesser efficiency compared to tyr-113, _128, and _145. Phosphorylation of slp-76 by the zap-70 protein-tyrosine kinase is required for t-cell receptor function |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-46859 |
Tyr128 |
DGEDDGDyESPNEEE |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 9047237 |
Zap-70 phosphorylates slp-76 at specific sites that allow vav sh2 domain bindingwe also show by in vitro and in vivo analysis that two slp-76 pyesp motifs (y113 and y128) mediate binding, the first being more efficient. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-42968 |
Tyr145 |
PVEDDADyEPPPSND |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 8702662 |
A fourth peptide derived from slp-76 encompassing tyr residues 423 and 426 was also phosphorylated by zap-70 but with a 10-15-fold lesser efficiency compared to tyr-113, _128, and _145. Phosphorylation of slp-76 by the zap-70 protein-tyrosine kinase is required for t-cell receptor function |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-42972 |
Tyr423 |
NSLNEEWyVSYITRP |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 8702662 |
A fourth peptide derived from slp-76 encompassing tyr residues 423 and 426 was also phosphorylated by zap-70 but with a 10-15-fold lesser efficiency compared to tyr-113, _128, and _145. Phosphorylation of slp-76 by the zap-70 protein-tyrosine kinase is required for t-cell receptor function |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-42976 |
Tyr426 |
NEEWYVSyITRPEAE |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 8702662 |
A fourth peptide derived from slp-76 encompassing tyr residues 423 and 426 was also phosphorylated by zap-70 but with a 10-15-fold lesser efficiency compared to tyr-113, _128, and _145. Phosphorylation of slp-76 by the zap-70 protein-tyrosine kinase is required for t-cell receptor function |
|
| Publications: |
7 |
Organism: |
Homo Sapiens |
| Pathways: | T cell activation |
| + |
TXK | up-regulates
phosphorylation
|
LCP2 |
0.717 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-44665 |
Tyr113 |
SSFEEDDyESPNDDQ |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 8892604 |
Resting lymphocyte kinase (rlk/txk) targets lymphoid adaptor slp-76 in the cooperative activation of interleukin-2 transcription in t-cells. In this study, we report that rlk phosphorylates slp-76 at its n-terminal yesp/yepp sites. A third tyrosine within the amino-terminal region (y145) appears to be the most important for optimal slp-76 function |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-74844 |
Tyr113 |
SSFEEDDyESPNDDQ |
Homo sapiens |
|
| pmid |
sentence |
| 10660534 |
Resting lymphocyte kinase (rlk/txk) targets lymphoid adaptor slp-76 in the cooperative activation of interleukin-2 transcription in t-cells. In this study, we report that rlk phosphorylates slp-76 at its n-terminal yesp/yepp sites. A third tyrosine within the amino-terminal region (y145) appears to be the most important for optimal slp-76 function |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-74848 |
Tyr145 |
PVEDDADyEPPPSND |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 10660534 |
Resting lymphocyte kinase (rlk/txk) targets lymphoid adaptor slp-76 in the cooperative activation of interleukin-2 transcription in t-cells. In this study, we report that rlk phosphorylates slp-76 at its n-terminal yesp/yepp sites. A third tyrosine within the amino-terminal region (y145) appears to be the most important for optimal slp-76 function |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-44669 |
Tyr145 |
PVEDDADyEPPPSND |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 8892604 |
Resting lymphocyte kinase (rlk/txk) targets lymphoid adaptor slp-76 in the cooperative activation of interleukin-2 transcription in t-cells. In this study, we report that rlk phosphorylates slp-76 at its n-terminal yesp/yepp sites. A third tyrosine within the amino-terminal region (y145) appears to be the most important for optimal slp-76 function |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
ZAP70 | up-regulates activity
phosphorylation
|
LCP2 |
0.798 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-102507 |
Tyr113 |
SSFEEDDyESPNDDQ |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 12817019 |
Phosphorylation of slp-76 is required for prolonged erk activation in response to sdf-1_ cr signal transduction results in slp-76 tyrosine phosphorylation at the amino-terminal tyrosines 113, 128, and 145 via a mechanism requiring the zap-70 tyrosine kinase. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-102511 |
Tyr128 |
DGEDDGDyESPNEEE |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 12817019 |
Phosphorylation of slp-76 is required for prolonged erk activation in response to sdf-1_ cr signal transduction results in slp-76 tyrosine phosphorylation at the amino-terminal tyrosines 113, 128, and 145 via a mechanism requiring the zap-70 tyrosine kinase. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-102515 |
Tyr145 |
PVEDDADyEPPPSND |
Homo sapiens |
|
| pmid |
sentence |
| 12817019 |
Phosphorylation of slp-76 is required for prolonged erk activation in response to sdf-1_ cr signal transduction results in slp-76 tyrosine phosphorylation at the amino-terminal tyrosines 113, 128, and 145 via a mechanism requiring the zap-70 tyrosine kinase. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | T cell activation |
| + |
TXK | up-regulates activity
phosphorylation
|
LCP2 |
0.717 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-246929 |
Tyr128 |
DGEDDGDyESPNEEE |
Homo sapiens |
|
| pmid |
sentence |
| 10660534 |
Rlk phosphorylated the N-terminal region of SLP-76, a region that has been previously shown to serve as a target for ZAP-70. Loss of N-terminal YESP/YEPP sites of SLP-76 or the Rlk kinase activity attenuated cooperativity between Rlk and SLP-76 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LCK |
phosphorylation
|
LCP2 |
0.744 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251381 |
Tyr423 |
NSLNEEWyVSYITRP |
in vitro |
|
| pmid |
sentence |
| 8702662 |
Ability of p56lck to phosphorylate Tyr-423/426 within SLP-76 in vitro |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251382 |
Tyr426 |
NEEWYVSyITRPEAE |
in vitro |
|
| pmid |
sentence |
| 8702662 |
Ability of p56lck to phosphorylate Tyr-423/426 within SLP-76 in vitro |
|
| Publications: |
2 |
Organism: |
In Vitro |
| Pathways: | T cell activation |
| + |
FYN | down-regulates
phosphorylation
|
LCP2 |
0.745 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-46851 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9047237 |
P59fyn_phosphorylated slp-76 at intermediate levels but, significantly, this phosphorylation failed to induce vav?SLP-76 complex formation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | T cell activation |
3.0
LCP2
- 
- 