Name	USP4 View Modifications
Full Name	Ubiquitin carboxyl-terminal hydrolase 4
Synonyms	EC 3.4.19.12, Deubiquitinating enzyme 4, Ubiquitin thioesterase 4, Ubiquitin-specific-processing protease 4, Ubiquitous nuclear protein homolog \| UNP, UNPH
Primary ID	Q13107
Links	- -
Type	protein
Relations	4
Function	Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins (PubMed:16316627, PubMed:16472766, PubMed:16339847, PubMed:20595234, PubMed:22347420, PubMed:25404403, PubMed:28604766). Deubiquitinates PDPK1 (PubMed:22347420). Deubiquitinates TRIM21 (PubMed:16316627). Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface (PubMed:16339847). Deubiquitinates HAS2 (PubMed:28604766). May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3 (PubMed:20595234). This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP (PubMed:20595234). May also play a role in the regulation of quality control in the ER (PubMed:16339847). {ECO:0000269\|PubMed:16316627, ECO:0000269\|PubMed:16339847, ECO:0000269\|PubMed:16472766, ECO:0000269\|PubMed:20595234, ECO:0000269\|PubMed:22347420, ECO:0000269\|PubMed:25404403, ECO:0000269\|PubMed:28604766}.