| + |
TBX2 | down-regulates activity 
binding
|
MYOG |
0.252 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251561 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24470334 |
We have found that TBX2 is highly up regulated in both ERMS and ARMS subtypes of RMS and demonstrate that TBX2 is a repressor of myogenesis by binding to MyoD and myogenin and inhibiting their activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rhabdomyosarcoma |
| + |
TBX2 | down-regulates 
|
Skeletal_muscle_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251563 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24470334 |
TBX2 blocks myogenesis and promotes proliferation in rhabdomyosarcoma cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rhabdomyosarcoma |
| + |
TBX2 | down-regulates quantity by repression
transcriptional regulation
|
CDKN2A |
0.502 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249594 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25211658 |
TBX2 and TBX3 function as transcriptional repressors and both have been shown to inhibit myogenesis (Carlson et al, 2002; Zhu et al, 2014). Abnormal expression of TBX2 has been reported in several cancers including breast, pancreas, and melanoma, where it has been shown to drive proliferation (reviewed in Abrahams et al (2010)). As has been previously shown in other cell types, TBX2 was found to induce a downregulation of p14/19ARF and function as a direct repressor of p21 in RMS |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TBX2 | down-regulates quantity by repression
transcriptional regulation
|
CDKN1A |
0.353 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249593 |
|
|
Homo sapiens |
Rhabdomyosarcoma Cell Line |
| pmid |
sentence |
| 25211658 |
TBX2 and TBX3 function as transcriptional repressors and both have been shown to inhibit myogenesis (Carlson et al, 2002; Zhu et al, 2014). Abnormal expression of TBX2 has been reported in several cancers including breast, pancreas, and melanoma, where it has been shown to drive proliferation (reviewed in Abrahams et al (2010)). As has been previously shown in other cell types, TBX2 was found to induce a downregulation of p14/19ARF and function as a direct repressor of p21 in RMS |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rhabdomyosarcoma |
| + |
PAX3 | up-regulates quantity by expression 
transcriptional regulation
|
TBX2 |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249596 |
|
|
Homo sapiens |
Rhabdomyosarcoma Cell Line |
| pmid |
sentence |
| 25211658 |
We have recently found that a T-box gene family member, TBX2, is highly overexpressed in both ERMS and ARMS cells (Zhu et al, 2014). The regulation of TBX2 is uncharacterised in RMS cells, but is likely to link TBX2 expression to the known deregulation of signalling pathways in RMS. In melanoma cells, TBX2 is regulated by PAX3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rhabdomyosarcoma |
| + |
TBX2 | up-regulates 
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251562 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24470334 |
TBX2 blocks myogenesis and promotes proliferation in rhabdomyosarcoma cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rhabdomyosarcoma |
| + |
TBX2 | down-regulates activity
binding
|
MYOD1 |
0.316 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251560 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24470334 |
We have found that TBX2 is highly up regulated in both ERMS and ARMS subtypes of RMS and demonstrate that TBX2 is a repressor of myogenesis by binding to MyoD and myogenin and inhibiting their activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rhabdomyosarcoma |
3.0
TBX2
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