| + |
SEMA3B | up-regulates activity 
binding
|
PLXNA4 |
0.649 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261810 |
|
|
Homo sapiens |
Endothelial Cell, U-87MG Cell |
| pmid |
sentence |
| 25335892 |
We provide evidence suggesting that, in endothelial cells and glioblastoma cells, plexin-A4 is a required component of both Sema3A and Sema3B receptor complexes and inhibition of its expression nullifies both Sema3A and Sema3B signaling. The specificity for Sema3A or Sema3B is determined by the presence of plexin-A1 in Sema3A receptors and plexin-A2 in Sema3B receptors, and silencing each abrogates signaling by the appropriate semaphorin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SEMA3B | up-regulates activity
binding
|
NRP2 |
0.609 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261816 |
|
|
Homo sapiens |
Endothelial Cell, U-87MG Cell |
| pmid |
sentence |
| 25335892 |
Further examination of the composition of the functional Sema3B receptor revealed that, unlike Sema3A, which signals exclusively using the NP1 receptor, Sema3B utilizes both NP1 and NP2 for signal transduction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SEMA3B | up-regulates activity
binding
|
NRP1 |
0.748 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261814 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25335892 |
Further examination of the composition of the functional Sema3B receptor revealed that, unlike Sema3A, which signals exclusively using the NP1 receptor, Sema3B utilizes both NP1 and NP2 for signal transduction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SEMA3B | up-regulates activity
binding
|
PLXNA2 |
0.651 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261812 |
|
|
Homo sapiens |
Endothelial Cell, U-87MG Cell |
| pmid |
sentence |
| 25335892 |
We provide evidence suggesting that, in endothelial cells and glioblastoma cells, plexin-A4 is a required component of both Sema3A and Sema3B receptor complexes and inhibition of its expression nullifies both Sema3A and Sema3B signaling. The specificity for Sema3A or Sema3B is determined by the presence of plexin-A1 in Sema3A receptors and plexin-A2 in Sema3B receptors, and silencing each abrogates signaling by the appropriate semaphorin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SEMA3B
- 
- 