Summary

Name FZD5
Full Name Frizzled-5
Synonyms Fz-5, hFz5, FzE5 | C2orf31
Primary ID Q13467
Links - -
Type protein
Relations 11
Function Receptor for Wnt proteins (PubMed:9054360, PubMed:10097073, PubMed:20530549). Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed (By similarity). In neurons, activation of WNT7A promotes formation of synapses (PubMed:20530549). Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ FZD5up-regulates activity img/direct-activation.png binding DVL1 0.645
Publications: 1 Organism: Homo Sapiens
+ FZD5down-regulates img/indirect_inhibition.png CEBPA 0.2
Publications: 1 Organism: Homo Sapiens
+ WNT5Aup-regulates img/direct-activation.png binding FZD5 0.826
Publications: 1 Organism: Homo Sapiens
+ FZD5up-regulates activity img/direct-activation.png binding DVL3 0.626
Publications: 1 Organism: Homo Sapiens
+ FZD5down-regulates img/indirect_inhibition.png PPARG 0.2
Publications: 1 Organism: Homo Sapiens
+ FZD5up-regulates activity img/direct-activation.png binding LRP6 0.727
Publications: 1 Organism: Homo Sapiens
+ WNT10Bup-regulates img/direct-activation.png binding FZD5 0.604
Publications: 1 Organism: Homo Sapiens
+ FZD5up-regulates activity img/direct-activation.png binding LRP5 0.657
Publications: 1 Organism: Homo Sapiens
+ FZD5up-regulates activity img/direct-activation.png binding DVL2 0.692
Publications: 1 Organism: Homo Sapiens
+ BAMBIup-regulates img/direct-activation.png binding FZD5 0.577
Publications: 1 Organism: Homo Sapiens
Tissue: Lung
+ ZNRF3down-regulates quantity img/direct_inhibition.png ubiquitination FZD5 0.495
Publications: 1 Organism: Homo Sapiens