| + |
TBK1 | up-regulates 
phosphorylation
|
IRF5 |
0.558 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-196528 |
Ser158 |
QRMLPSLsLTEDVKW |
Homo sapiens |
|
| pmid |
sentence |
| 22412986 |
Activation of interferon regulatory factor 5 by site specific phosphorylation. Although the gene induction by irf5 in the presence of tbk-1 was modest, phosphorylation by tbk-1 produced a significant shift in the mobility of irf5 in sds-page. For this reason we identified the residues that are phosphorylated on irf5 by tbk-1 with mass spectrometry. Ser-158 and ser-309 were found to be phosphorylated |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-196532 |
Ser293 |
VELFGPIsLEQVRFP |
Homo sapiens |
|
| pmid |
sentence |
| 22412986 |
Activation of interferon regulatory factor 5 by site specific phosphorylation. Although the gene induction by irf5 in the presence of tbk-1 was modest, phosphorylation by tbk-1 produced a significant shift in the mobility of irf5 in sds-page. For this reason we identified the residues that are phosphorylated on irf5 by tbk-1 with mass spectrometry. Ser-158 and ser-309 were found to be phosphorylated |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
RIPK2 | up-regulates
phosphorylation
|
IRF5 |
0.31 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-196520 |
Ser435 |
EMFSGELsWSADSIR |
Homo sapiens |
|
| pmid |
sentence |
| 22412986 |
Activation of interferon regulatory factor 5 by site specific phosphorylation. Phosphorylation of carboxyl serines 451 and 462 appear the primary trigger of irf5 function in nuclear accumulation, transcription, and apoptosis. Rip2 activation of the irf5 aspartic acid substitutions showed a similar positive effect of s451d and s462d function in this assay |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-196524 |
Ser446 |
DSIRLQIsNPDLKDR |
Homo sapiens |
|
| pmid |
sentence |
| 22412986 |
Activation of interferon regulatory factor 5 by site specific phosphorylation. Phosphorylation of carboxyl serines 451 and 462 appear the primary trigger of irf5 function in nuclear accumulation, transcription, and apoptosis. Rip2 activation of the irf5 aspartic acid substitutions showed a similar positive effect of s451d and s462d function in this assay |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
LYN | down-regulates activity 
phosphorylation
|
IRF5 |
0.335 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277247 |
Tyr313 |
PSDKQRFyTNQLLDV |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 27521268 |
Lyn Kinase Suppresses the Transcriptional Activity of IRF5. Here, we found that Lyn physically interacted with IRF5 to inhibit ubiquitination and phosphorylation of IRF5 in the TLR-MyD88 pathway, thereby suppressing the transcriptional activity of IRF5 in a manner independent of Lyn's kinase activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277248 |
Tyr335 |
QLQGQDLyAIRLCQC |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 27521268 |
Lyn Kinase Suppresses the Transcriptional Activity of IRF5. Here, we found that Lyn physically interacted with IRF5 to inhibit ubiquitination and phosphorylation of IRF5 in the TLR-MyD88 pathway, thereby suppressing the transcriptional activity of IRF5 in a manner independent of Lyn's kinase activity. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
STAT5A | up-regulates quantity by expression
transcriptional regulation
|
IRF5 |
0.292 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249508 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 25506346 |
The GM-CSF receptor forms a dodecamer structure and recruits JAK2, leading to the activation of STAT5, extracellular signal-regulated kinase (ERK), V-Akt murine thymoma viral oncogene homolog 1 (AKT), and the nuclear translocation of NF-kappaB and IRF5 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IRF5 | up-regulates 
transcriptional regulation
|
IL1B |
0.297 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255340 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 26315890 |
IL-1b was present in the sera of wild-type mice but was not detected in the sera of IRF5-/- mice |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254510 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 21240265 |
Among the genes with differences in expression in the M1 and M2 subsets are those regulated by IRF5, including IL12A, IL12B, IL23A, IL1B, TNF, CCL3(encoding MIP-1α), RANTES, CD1A, CD40, CD86 and CCR7 |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| + |
IRF5 | up-regulates
|
M1_polarization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249562 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22378047 |
IL-4-induced c-Myc activity controls a subset of M2-associated genes. IL-4 also induces the M2-polarizing JMJD3-IRF4 axis to inhibit IRF5-mediated M1 polarization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IRF5 | down-regulates 
transcriptional regulation
|
IL10 |
0.436 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254514 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 21240265 |
The role of IRF5 in inhibiting the transcription of the gene encoding IL-10 that we have identified here is important given its well- documented immunosuppressive activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IRF4 | down-regulates activity
|
IRF5 |
0.433 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249560 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 22378047 |
IL-4-induced c-Myc activity controls a subset of M2-associated genes. IL-4 also induces the M2-polarizing JMJD3-IRF4 axis to inhibit IRF5-mediated M1 polarization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IRF5 | down-regulates quantity by repression
transcriptional regulation
|
IL10 |
0.436 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249509 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 22025054 |
IRF5 is directly recruited to gene promoters associated with the M1 phenotype (including Il12b), but it represses Il10, probably also by binding to an ISRE in the gene promoter |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IRF5 | up-regulates quantity by expression
transcriptional regulation
|
TNF |
0.465 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254518 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21240265 |
Among the genes with differences in expression in the M1 and M2 subsets are those regulated by IRF5, including IL12A, IL12B, IL23A, IL1B, TNF, CCL3(encoding MIP-1α), RANTES, CD1A, CD40, CD86 and CCR7 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
IRF5
- 
- 