Summary

Name CUL4A
Full Name Cullin-4A
Synonyms CUL-4A
Primary ID Q13619
Links - -
Type protein
Relations 4
Function Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL. The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). With CUL4B, contributes to ribosome biogenesis (PubMed:26711351).

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Relations

Regulator Mechanism target score ℹ
+ CUL4Aup-regulates activity img/direct-activation.png binding ARIH1 0.284
Publications: 1 Organism: Homo Sapiens
+ CUL4Aform complex img/form-complex.png binding DCX DET1-COP1 0.897
Publications: 1 Organism: Homo Sapiens
+ NAEup-regulates activity img/direct-activation.png neddylation CUL4A 0.611
Publications: 1 Organism: Homo Sapiens
+ CUL4Aform complex img/form-complex.png binding Cullin4-RBX1-DDB1 0.899
Publications: 1 Organism: Homo Sapiens