| + |
NAE | up-regulates activity 
neddylation
|
CUL9 |
0.488 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243169 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25504797 |
The family of cullin proteins is the most established target for NEDD8. In humans, it is composed of seven cullins (Cul1, 2, 3, 4A, 4B, 5 and 7), whereas PARC (CUL9) and APC2 (component of the anaphase promoting complex APC) contain a cullin-homology domain. All cullins are modified with NEDD8The role of cullin NEDDylation is to enhance the activity of the CRLs and subsequent ubiquitination and degradation of the regulated substrates. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NAE | up-regulates activity
neddylation
|
CUL3 |
0.593 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243157 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25504797 |
The family of cullin proteins is the most established target for NEDD8. In humans, it is composed of seven cullins (Cul1, 2, 3, 4A, 4B, 5 and 7), whereas PARC (CUL9) and APC2 (component of the anaphase promoting complex APC) contain a cullin-homology domain. All cullins are modified with NEDD8The role of cullin NEDDylation is to enhance the activity of the CRLs and subsequent ubiquitination and degradation of the regulated substrates. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NAE | up-regulates activity
neddylation
|
CUL5 |
0.641 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243166 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25504797 |
The family of cullin proteins is the most established target for NEDD8. In humans, it is composed of seven cullins (Cul1, 2, 3, 4A, 4B, 5 and 7), whereas PARC (CUL9) and APC2 (component of the anaphase promoting complex APC) contain a cullin-homology domain. All cullins are modified with NEDD8The role of cullin NEDDylation is to enhance the activity of the CRLs and subsequent ubiquitination and degradation of the regulated substrates. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NAE | up-regulates activity
neddylation
|
CUL4B |
0.62 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243163 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25504797 |
The family of cullin proteins is the most established target for NEDD8. In humans, it is composed of seven cullins (Cul1, 2, 3, 4A, 4B, 5 and 7), whereas PARC (CUL9) and APC2 (component of the anaphase promoting complex APC) contain a cullin-homology domain. All cullins are modified with NEDD8The role of cullin NEDDylation is to enhance the activity of the CRLs and subsequent ubiquitination and degradation of the regulated substrates. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
UBA3 | form complex 
binding
|
NAE |
0.967 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242904 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25504797 |
the NEDD8 E1-activating enzyme (NAE) is a heterodimer of APPBP1 and UBA3 corresponding to the N-terminal and C-terminal of the single polypeptide of the ubiquitin E1 respectively |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NAE | up-regulates activity
neddylation
|
CUL2 |
0.537 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243154 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25504797 |
The family of cullin proteins is the most established target for NEDD8. In humans, it is composed of seven cullins (Cul1, 2, 3, 4A, 4B, 5 and 7), whereas PARC (CUL9) and APC2 (component of the anaphase promoting complex APC) contain a cullin-homology domain. All cullins are modified with NEDD8The role of cullin NEDDylation is to enhance the activity of the CRLs and subsequent ubiquitination and degradation of the regulated substrates. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NAE | up-regulates activity
neddylation
|
ANAPC2 |
0.41 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243175 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25504797 |
The family of cullin proteins is the most established target for NEDD8. In humans, it is composed of seven cullins (Cul1, 2, 3, 4A, 4B, 5 and 7), whereas PARC (CUL9) and APC2 (component of the anaphase promoting complex APC) contain a cullin-homology domain. All cullins are modified with NEDD8The role of cullin NEDDylation is to enhance the activity of the CRLs and subsequent ubiquitination and degradation of the regulated substrates. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NAE1 | form complex
binding
|
NAE |
0.967 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242907 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25504797 |
the NEDD8 E1-activating enzyme (NAE) is a heterodimer of APPBP1 and UBA3 corresponding to the N-terminal and C-terminal of the single polypeptide of the ubiquitin E1 respectively |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NAE | up-regulates activity
neddylation
|
CUL1 |
0.75 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243151 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25504797 |
The family of cullin proteins is the most established target for NEDD8. In humans, it is composed of seven cullins (Cul1, 2, 3, 4A, 4B, 5 and 7), whereas PARC (CUL9) and APC2 (component of the anaphase promoting complex APC) contain a cullin-homology domain. All cullins are modified with NEDD8The role of cullin NEDDylation is to enhance the activity of the CRLs and subsequent ubiquitination and degradation of the regulated substrates. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NAE | up-regulates activity
neddylation
|
CUL7 |
0.471 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243172 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25504797 |
The family of cullin proteins is the most established target for NEDD8. In humans, it is composed of seven cullins (Cul1, 2, 3, 4A, 4B, 5 and 7), whereas PARC (CUL9) and APC2 (component of the anaphase promoting complex APC) contain a cullin-homology domain. All cullins are modified with NEDD8The role of cullin NEDDylation is to enhance the activity of the CRLs and subsequent ubiquitination and degradation of the regulated substrates. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NAE | up-regulates activity
neddylation
|
CUL4A |
0.631 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243160 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25504797 |
The family of cullin proteins is the most established target for NEDD8. In humans, it is composed of seven cullins (Cul1, 2, 3, 4A, 4B, 5 and 7), whereas PARC (CUL9) and APC2 (component of the anaphase promoting complex APC) contain a cullin-homology domain. All cullins are modified with NEDD8The role of cullin NEDDylation is to enhance the activity of the CRLs and subsequent ubiquitination and degradation of the regulated substrates. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
NAE
CPX-2587