Summary

Name IL10RA
Full Name Interleukin-10 receptor subunit alpha
Synonyms IL-10 receptor subunit alpha, IL-10R subunit alpha, IL-10RA, CDw210a, Interleukin-10 receptor subunit 1, IL-10R subunit 1, IL-10R1 | IL10R
Primary ID Q13651
Links - -
Type protein
Relations 9
Pathways Macrophage polarization, Macrophage: IL10, Macrophage: Polarization and myogenesis, Multiple sclerosis, SARS-CoV CYTOKINE STORM, T-Lymphocyte: IL10
Function Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well (PubMed:16982608). In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively (PubMed:12133952). These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy (PubMed:26962683).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation IL10RA 0.799
Publications: 2
Pathways:Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ up-regulates activity img/direct-activation.png , binding JAK1 0.799
Publications: 2 Organism: Homo Sapiens
Pathways:Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ up-regulates img/indirect-activation.png Phagocytosis 0.7
Publications: 2
+ up-regulates activity img/direct-activation.png binding IL10RA 0.911
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ up-regulates activity img/direct-activation.png phosphorylation JAK2 0.418
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization
+ up-regulates img/direct-activation.png binding IL10RA 0.911
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization, Multiple sclerosis, SARS-CoV CYTOKINE STORM