4.0
Macrophage polarization
Pathway ID: SIGNOR-M1M2View in NDEx
Description: Macrophages constitute a very heterogeneous population of phagocytic cells, involved in immune-related and non-immune related processes and therefore, depending upon their immediate environment, can have very distinct phenotypes. One of the most popular classification divides activated macrophages into 2 categories: M1, known as “pro-inflammatory” and M2, known as “anti-inflammatory” macrophages. M1s are induced by IFNg, microbial stimuli (such as PAMPs), or cytokines, while M2s are induced by IL4, Il10 and IL13.
Curated by: Alessandro Palma
Description: Macrophages constitute a very heterogeneous population of phagocytic cells, involved in immune-related and non-immune related processes and therefore, depending upon their immediate environment, can have very distinct phenotypes. One of the most popular classification divides activated macrophages into 2 categories: M1, known as “pro-inflammatory” and M2, known as “anti-inflammatory” macrophages. M1s are induced by IFNg, microbial stimuli (such as PAMPs), or cytokines, while M2s are induced by IL4, Il10 and IL13.
Curated by: Alessandro Palma
26 Seed Entities
Organism: 
|
Name | Primary ID |
|---|---|
| STAT6 | P42226 |
| IL10 | P22301 |
| IL10RA | Q13651 |
| M1_polarization | SIGNOR-PH54 |
| IL4 | P05112 |
| IL4R | P24394 |
| MAP3K1 | Q13233 |
| TICAM1 | Q8IUC6 |
| IL13 | P35225 |
| STAT3 | P40763 |
| IRF4 | Q15306 |
| PAMPs | SIGNOR-ST11 |
| IFNGR2/INFGR1 | SIGNOR-C142 |
| PPARG | P37231 |
| RIPK1 | Q13546 |
| M2_polarization | SIGNOR-PH55 |
| IFNG | P01579 |
| IKK-complex | SIGNOR-C14 |
| JAK2 | O60674 |
| SOCS1 | O15524 |
| NfKb-p65/p50 | SIGNOR-C13 |
| TLR4 | O00206 |
| MAP2K4 | P45985 |
| MAPK8 | P45983 |
| TICAM2 | Q86XR7 |
| KDM6B | O15054 |