| + |
KEAP1 | down-regulates quantity 
ubiquitination
|
NFE2L2 |
0.808 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259335 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31257023 |
Keap1 is a substrate receptor of a Cul3-RING ubiquitin ligase (CRL3) that, in physiological conditions, constitutively binds and targets Nrf2 for degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hepatocellular Tumor |
| + |
KEAP1 | down-regulates quantity by destabilization
binding
|
PGAM5 |
0.568 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272645 |
|
|
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 17046835 |
Keap1-dependent ubiquitination of PGAM5 results in proteasome-dependent degradation of PGAM5. Keap1 is a Bric-a-Brac (BTB) 2 -Kelch protein that functions as a substrate adaptor protein for a Cul3-dependent E3 ubiquitin ligase complex. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
KEAP1 | up-regulates activity 
binding
|
CUL3 |
0.949 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268925 |
|
|
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 15983046 |
Keap1 is a BTB-Kelch protein that functions as a substrate adaptor protein for a Cul3-dependent E3 ubiquitin ligase complex. Keap1 targets its substrate, the Nrf2 transcription factor, for ubiquitination and subsequent degradation by the 26 S proteasome. The N-terminal BTB domain and central linker region of Keap1 bind Cul3, whereas the C-terminal Kelch domain of Keap1 binds Nrf2 via residues located within loops that extend out from the bottom of the Kelch domain |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
KEAP1 | up-regulates activity
binding
|
Cullin 3-RBX1-Skp1 |
0.712 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272646 |
|
|
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 17046835 |
Keap1-dependent ubiquitination of PGAM5 results in proteasome-dependent degradation of PGAM5. Keap1 is a Bric-a-Brac (BTB) 2 -Kelch protein that functions as a substrate adaptor protein for a Cul3-dependent E3 ubiquitin ligase complex. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
BAP1 | up-regulates quantity by stabilization
binding
|
KEAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268924 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 35052618 |
BAP1 directly binds to and deubiquitinates KEAP1. BAP1 stabilizes KEAP1 by binding to the BTB domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DPP3 | down-regulates quantity by destabilization
cleavage
|
KEAP1 |
0.617 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268464 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35278345 |
The influence of DPP3 on the Keap1-Nrf2/ARE signal pathway suggest a direct involvement of DPP3 in the oxidative stress response [8,14,31,53,99,100]. It was shown that DPP3 competes with Nrf2 through the ETGE motif to bind to Keap1 and consequently enhances the translocation of Nrf2 to the nucleus, thereby driving the expression of an array of genes encoding antioxidative enzymes [99]. More specifically, binding of DPP3 to Keap1 releases Nrf2, and thus, prevents its degradation through the 26S proteasome |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KEAP1 | down-regulates
binding
|
NFE2L2 |
0.808 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205229 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24997453 |
Keap1 is an oxidative stress-sensing protein and is a negative regulator of nuclear factor-erythroid-2-related factor 2 (nrf2). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hepatocellular Tumor |
3.0
KEAP1
- 
- 