3.0
Summary
| Name |  PGAM5View Modifications |
| Full Name | Serine/threonine-protein phosphatase PGAM5, mitochondrial |
| Synonyms | EC 3.1.3.16, Bcl-XL-binding protein v68, Phosphoglycerate mutase family member 5 | |
| Primary ID | Q96HS1 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore. {ECO:0000269|PubMed:18387606, ECO:0000269|PubMed:19590015, ECO:0000269|PubMed:22265414}. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PGAM5 | up-regulates activity 
dephosphorylation
|
ME1 | 0.2 |
| Publications: | 1 | |||
| + | Cullin 3-RBX1-Skp1 | down-regulates quantity by destabilization 
polyubiquitination
|
PGAM5 | 0.418 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | PGAM5 | up-regulates activity
dephosphorylation
|
FUNDC1 | 0.617 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KEAP1 | down-regulates quantity by destabilization
binding
|
PGAM5 | 0.568 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |