3.0
Summary
| Name |  PCM1View Modifications |
| Full Name | Pericentriolar material 1 protein |
| Synonyms | PCM-1, hPCM-1 |
| Primary ID | Q15154 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Function | Required for centrosome assembly and function (PubMed:12403812, PubMed:15659651, PubMed:16943179). Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (PubMed:12403812, PubMed:15659651). Required to anchor microtubules to the centrosome (PubMed:12403812, PubMed:15659651). Involved in the biogenesis of cilia (PubMed:20551181, PubMed:24121310). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PLK4 | up-regulates activity 
phosphorylation
|
PCM1 | 0.571 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PCM1 | up-regulates
relocalization
|
NIN | 0.405 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PCM1 | up-regulates
relocalization
|
NEK2 | 0.423 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PCM1 | up-regulates
relocalization
|
CEP250 | 0.549 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PCM1 | up-regulates
relocalization
|
CETN3 | 0.296 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PCM1 | up-regulates
relocalization
|
PCNT | 0.687 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MIB1 | down-regulates 
ubiquitination
|
PCM1 | 0.373 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PCM1 | up-regulates
relocalization
|
CETN2 | 0.529 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PCM1 | up-regulates
relocalization
|
CETN1 | 0.405 |
| Publications: | 1 | Organism: | Homo Sapiens | |