Summary

Name NIN
Full Name Ninein
Synonyms hNinein, Glycogen synthase kinase 3 beta-interacting protein, GSK3B-interacting protein | KIAA1565
Primary ID Q8N4C6
Links - -
Type protein
Relations 2
Function Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061).

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png relocalization NIN 0.421
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding JAK2 0.245
Publications: 1 Organism: Homo Sapiens