Summary

Name ELOC
Full Name Elongin-C
Synonyms Elongin 15 kDa subunit, Elongin-C, EloC, RNA polymerase II transcription factor SIII subunit C, SIII p15
Primary ID Q15369
Links - -
Type protein
Relations 5
Function SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7821821). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation H1-1 0.2
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding VCB-Cul2 0.2
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Elongin E3-Cul-5 0.2
Publications: 1 Organism: Mus Musculus
+ form complex img/form-complex.png binding BAF250b E3 ligase 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination NOTCH4 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Hindbrain