Summary

Name NOTCH4
Full Name Neurogenic locus notch homolog protein 4
Synonyms Notch 4, hNotch4 | INT3
Primary ID Q99466
Links - -
Type protein
Relations 10
Function Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding NOTCH4 0.859
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAML2 0.851
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH4 0.696
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NOTCH4 0.319
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination NOTCH4 0.518
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAML3 0.859
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HEY2 0.6
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination NOTCH4 0.379
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates activity img/direct-activation.png cleavage NOTCH4 0.512
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination NOTCH4 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Hindbrain