+ |
Cullin 1-RBX1-Skp1 | down-regulates quantity by destabilization
polyubiquitination
|
NFKBIB |
0.445 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272556 |
|
|
Chlorocebus aethiops |
COS Cell |
pmid |
sentence |
10514424 |
Interaction with beta-TrCP is also necessary for ubiquitination of IkappaBbeta upon stimulation of cells, and deletion of the F-box in beta-TrCP abolishes its ability to ubiquitinate IkappaBbeta. Therefore, these results indicate that beta-TrCP plays a critical role in the activation of NF-kappaB by assembling the ubiquitin ligase complex for both phosphorylated IkappaBalpha and IkappaBbeta.β-TrCP recognizes IκBα phosphorylated at Ser-32 and Ser-36 through its WD40 domain, whereas the F-box motif recruits additional proteins including Skp1 and Cullin to form the Skp1-cullin-F-box (SCF) ubiquitin ligase complex |
|
Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
+ |
MAP3K7 | down-regulates
phosphorylation
|
NFKBIB |
0.494 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-55719 |
|
|
Homo sapiens |
|
pmid |
sentence |
9480845 |
Overexpression oftak1together with its activator protein,tak1binding protein 1 (tab1), induced thenucleartranslocation of nf-kappa b p50/p65 heterodimer accompanied by the degradation of i kappa b alpha and i kappa b beta, and the expression of kappa b-dependent reporter gene. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
BTRC | down-regulates quantity by destabilization
binding
|
NFKBIB |
0.564 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272554 |
|
|
Chlorocebus aethiops |
COS Cell |
pmid |
sentence |
10514424 |
Interaction with beta-TrCP is also necessary for ubiquitination of IkappaBbeta upon stimulation of cells, and deletion of the F-box in beta-TrCP abolishes its ability to ubiquitinate IkappaBbeta. Therefore, these results indicate that beta-TrCP plays a critical role in the activation of NF-kappaB by assembling the ubiquitin ligase complex for both phosphorylated IkappaBalpha and IkappaBbeta.β-TrCP recognizes IκBα phosphorylated at Ser-32 and Ser-36 through its WD40 domain, whereas the F-box motif recruits additional proteins including Skp1 and Cullin to form the Skp1-cullin-F-box (SCF) ubiquitin ligase complex |
|
Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
+ |
IKBKB | down-regulates
phosphorylation
|
NFKBIB |
0.757 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-52932 |
|
|
Homo sapiens |
|
pmid |
sentence |
9346241 |
We described the purification of a 900 kda protein kinase complex, the ikb kinase (ikk), that phosphorylates ikbalfa and ikbbeta at the sites that mediate their ubiquitination and degradation |
|
Publications: |
1 |
Organism: |
Homo Sapiens |