4.0
Summary
| Name |  FSCN1View Modifications |
| Full Name | Fascin |
| Synonyms | 55 kDa actin-bundling protein, Singed-like protein, p55 | FAN1, HSN, SNL |
| Primary ID | Q16658 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Pathways | Axon guidance |
| Function | Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945). Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCD | down-regulates activity 
phosphorylation
|
FSCN1 | 0.323 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FSCN1 | up-regulates 
|
Actin_cytoskeleton_reorganization | 0.7 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | Axon guidance | |||
| + | PLXNB3 | up-regulates activity
|
FSCN1 | 0.334 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | Axon guidance | |||