| + |
ORF6 | down-regulates activity 
|
STAT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260271 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 17596301 |
Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
ORF6 | down-regulates activity 
relocalization
|
KPNA2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260272 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 17596301 |
Taken together, these data support a direct interaction between KPNA2 and ORF6 in the context of virus infection.|SARS-CoV, but not SARSdeltaORF6, retains KPNA2 at the ER/Golgi membrane. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
ORF6 | down-regulates activity
relocalization
|
KPNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260275 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 17596301 |
ORF6 also retained KPNB1 at the ER/Golgi membrane in complex with KPNA2. Deletion of the N terminus of KPNA2, which binds KPNB1, no longer retained KPNB1 at the ER/Golgi membrane in the presence of ORF6 and did not antagonize STAT1 nuclear import in response to IFN-beta |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
4.0
ORF6
- 
- 