4.0
Summary
| Name |  LRRFIP1
|
| Full Name | Leucine-rich repeat flightless-interacting protein 1 |
| Synonyms | LRR FLII-interacting protein 1, GC-binding factor 2, TAR RNA-interacting protein | GCF2, TRIP |
| Primary ID | Q32MZ4 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. |
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transcriptional regulation
phosphorylation