Summary

Name PLEKHG6
Full Name Pleckstrin homology domain-containing family G member 6
Synonyms PH domain-containing family G member 6, Myosin-interacting guanine nucleotide exchange factor, MyoGEF
Primary ID Q3KR16
Links - -
Type protein
Relations 4
Function Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation PLEKHG6 0.258
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLEKHG6 0.431
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.303
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.563
Publications: 1 Organism: Homo Sapiens