Summary

Name ANO6
Full Name Anoctamin-6
Synonyms Small-conductance calcium-activated nonselective cation channel, SCAN channel, Transmembrane protein 16F | TMEM16F
Primary ID Q4KMQ2
Links - -
Type protein
Relations 2
Function Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/indirect-activation.png ERK1/2 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png Proliferation 0.7
Publications: 1 Organism: Mus Musculus