| + |
LRFN4 | up-regulates 
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264097 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 21736948 |
This study finds that all SALMs (SALMs 1–5) possess the abilityto promote neurite outgrowth and branching, as demonstrated byoverexpression and knockdown experiments. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LRFN4 | up-regulates
|
Synaptic_plasticity |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264092 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 21736948 |
The SALM (synaptic adhesion-like molecule) family of adhesion molecules, also known as Lrfn, belongs to the superfamily of leucine-rich repeat (LRR)-containing adhesion molecules. Proteins of the SALM family, which includes five known members (SALMs 1-5), have been implicated in the regulation of neurite outgrowth and branching, and synapse formation and maturation.SALM3 and SALM5, but not other SALMs, possess synaptogenic activity, inducing presynaptic differentiation in contacting axons. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LRFN4 | up-regulates activity 
binding
|
DLG4 |
0.67 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264096 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 21736948 |
SALMs 1-3 contain a C-terminal PDZ-binding motif, which interacts with PSD-95, an abundant postsynaptic scaffolding protein, whereas SALM4 and SALM5 lack PDZ binding. One possibility is that SALM3, which is capable of inducing presynaptic differentiation in contacting axons [19], recruits PSD-95 or SAP102 to the sites of early synaptic adhesion. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
LRFN4
- 
- 